Manufacturing nanostructured chitosan-based 2D sheets with prolonged antimicrobial activity

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dc.authoridKaya, Durmus Alpaslan/0000-0003-3544-9214
dc.authoridFICAI, Anton/0000-0002-1777-0525
dc.authoridDitu, Lia-Mara/0000-0002-6593-255X
dc.authoridSonmez, Maria/0000-0003-1749-9533
dc.authoridHolban, Alina/0000-0002-1257-5042
dc.contributor.authorFicai, Denisa
dc.contributor.authorArdelean, Ioana Lavinia
dc.contributor.authorHolban, Alina Maria
dc.contributor.authorDitu, Lia Mara
dc.contributor.authorGudovan, Dragos
dc.contributor.authorSonmez, Maria
dc.contributor.authorTrusca, Roxana
dc.date.accessioned2024-09-18T20:08:21Z
dc.date.available2024-09-18T20:08:21Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe purpose of this study was to synthesize, characterize and test the antimicrobial and antifungal activity of chitosan-based hydrogels containing metal (silver - Ag) and oxide (zinc oxide - ZnO) nanoparticles (NPs) but also natural compounds such as usnic acid (UA). The two-dimensional (2D) sheets were obtained by electrospinning technique, with the aim to produce multifunctional wound dressing with regenerative and even anti-infective roles. The most important advantages of the electrospinning technique are related to the possibility of obtaining fibers with controlled morphology, usually having high specific surface and water and air penetration and the possibility of functionalizing these fibers and nets depending on the desired application. These advantages make it possible to use electrospinning for a wide range of biomedical applications, such as tissue engineering, controlled release, implantology, wound healing, and more. The obtained composite materials were characterized by infrared (IR) spectroscopy and scanning electron microscopy (SEM) and tested against common pathogens: Pseudomonas aeruginosa (Gram-negative staining), Staphylococcus aureus (Gram-positive staining) and Candida albicans (fungus).en_US
dc.identifier.endpage525en_US
dc.identifier.issn1220-0522
dc.identifier.issue2en_US
dc.identifier.pmid30173257en_US
dc.identifier.scopus2-s2.0-85052752325en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage517en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8785
dc.identifier.volume59en_US
dc.identifier.wosWOS:000444860300012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherEditura Acad Romaneen_US
dc.relation.ispartofRomanian Journal of Morphology and Embryologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchitosanen_US
dc.subjecthydrogelsen_US
dc.subjectmultifunctional wound dressingen_US
dc.subjectcomposite materialsen_US
dc.subjectbiomedical applicationsen_US
dc.titleManufacturing nanostructured chitosan-based 2D sheets with prolonged antimicrobial activityen_US
dc.typeArticleen_US

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