Nobiletin attenuates acetaminophen-induced hepatorenal toxicity in rats

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dc.authoridOzkan, Huseyin/0000-0001-5753-8985
dc.authoridGOKCEK, ISHAK/0000-0002-0590-6405
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.contributor.authorGuvenc, Mehmet
dc.contributor.authorCellat, Mustafa
dc.contributor.authorGokcek, Ishak
dc.contributor.authorOzkan, Huseyin
dc.contributor.authorArkali, Gozde
dc.contributor.authorYakan, Akin
dc.contributor.authorOzsoy, Sule Yurdagul
dc.date.accessioned2024-09-18T19:48:02Z
dc.date.available2024-09-18T19:48:02Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe study aimed to examine the effects of nobiletin on the toxicity model induced with acetaminophen (APAP). For this purpose, 24 adult male rats were equally divided into four groups. The groups were the control group (group 1); dimethyl sulfoxide only, the APAP group (group 2) received a single dose of APAP 1000 mg/kg on the 10th day of experiment; the Nobiletin group (group 3), nobiletin (10 mg/kg) for 10 days; and the APAP + Nobiletin group (group 4), nobiletin (10 mg/kg) for 10 days with a single dose of APAP (1000 mg/kg) administered on the 10th day and the experiment ended after 48 hours. At the end of the study, a significant increase in malondialdehyde, interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) levels and a significant decrease in glutathione levels, glutathione peroxidase activities and nuclear factor erythroid-derived 2-like 2 (Nrf-2) and heme oxygenase-1 (HO-1) expressions were observed with APAP application in liver and kidney tissues. Serum aspartate transaminase (AST), alanine transaminase (ALT), urea, and creatinine levels were also significantly increased in the APAP group. However, nobiletin treatment in group 4 reversed oxidative stress and inflammatory and histopathological signs caused by APAP. It is concluded that nobiletin may be a beneficial substance that confers hepatorenal protection to APAP-induced toxicity via antioxidant and anti-inflammatory mechanisms.en_US
dc.description.sponsorshipMustafa Kemal Universitesi [17, M.006]en_US
dc.description.sponsorshipMustafa Kemal Universitesi, Grant/Award Number: 17.M.006en_US
dc.identifier.doi10.1002/jbt.22427
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue2en_US
dc.identifier.pmid31777137en_US
dc.identifier.scopus2-s2.0-85075744129en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.22427
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7313
dc.identifier.volume34en_US
dc.identifier.wosWOS:000498857000001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacetaminophenen_US
dc.subjectnobiletinen_US
dc.subjectNrf-2en_US
dc.subjectHO-1en_US
dc.subjectoxidative stressen_US
dc.titleNobiletin attenuates acetaminophen-induced hepatorenal toxicity in ratsen_US
dc.typeArticleen_US

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