Chemical Composition of Myrtus communis L. and Proapoptotic Effects on the A549 Cell Line

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dc.authoridErcin, Nilufer/0000-0003-0137-4963
dc.contributor.authorBilgic, Nilufer
dc.contributor.authorDuran, Gulay Gulbol
dc.date.accessioned2024-09-18T20:02:34Z
dc.date.available2024-09-18T20:02:34Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe aim of this study was to analyze the essential oils of Myrtus communis L.from the south of Turkey by the GC/MS method and to demonstrate its proapoptotic effects on A549 cells. A549 cells were used as cell lines in the study. Cells were treated for 24 hours with a different concentration of the essential oil (from 200 to 31.25 mu g/ml). Non-toxic concentrations of essential oils of MC were determined by the MTT method. Apoptosis studies were performed within the determined non-toxic concentrations of essential oils. Expression levels of the caspase 3, caspase 8, caspase 9, Bcl-2, and p21 genes were performed by qRT-PCR method. Eucalyptol (1,8-cineole; 31.2 %) was found at the highest rate in the essential oils content, while alphapinene followed it with a rate of 29.6 %. Our results showed that essential oil concentrations of 625 mu g/ml and higher than this concentration significantly suppressed cell viability at the end of the 24-hour incubation compared to the control group. The expression levels of caspase 3 and caspase 9 genes, which are the mediators of the intrinsic pathway, increased statistically significantly at the essential oil concentration of 312.5 mu g/ml (respectively, p=0.0129 and p=0.0180). The expression level of the p21 gene was significantly increased at a concentration of 156.25 mu g/ml essential oils (p=0.0002). The essential oils of MC from the South of Turkey have been found to induce apoptosis intrinsically. These findings could be a guide in understanding the molecular mechanism underlying the anti-cancer properties of MC's essential oils on A549 cells. We think that it has the potential to be a new natural therapeutic agent for cancer treatment.en_US
dc.identifier.doi10.1080/0972060X.2020.1866681
dc.identifier.endpage1295en_US
dc.identifier.issn0972-060X
dc.identifier.issn0976-5026
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85100134344en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1283en_US
dc.identifier.urihttps://doi.org/10.1080/0972060X.2020.1866681
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7867
dc.identifier.volume23en_US
dc.identifier.wosWOS:000607299300008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Essential Oil Bearing Plantsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectcanceren_US
dc.subjectA549 cell lineen_US
dc.subjectMyrtus communis L.en_US
dc.subjectessential oilsen_US
dc.titleChemical Composition of Myrtus communis L. and Proapoptotic Effects on the A549 Cell Lineen_US
dc.typeArticleen_US

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