Histological and morphological development of the prepuce from birth to prepubertal age

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dc.authoridCoskun Yilmaz, Banu/0000-0002-7723-9146
dc.authoridAkbay, Erdem/0000-0001-7669-414X
dc.authoridAygun, Yuksel Cem/0000-0002-6232-4313
dc.contributor.authorErdem, Erim
dc.contributor.authorCaliskan, Mustafa Kaplan
dc.contributor.authorKaragul, Meryem Ilkay
dc.contributor.authorAkbay, Erdem
dc.contributor.authorYilmaz, Banu Coskun
dc.contributor.authorAygun, Yuksel Cem
dc.date.accessioned2024-09-18T19:54:19Z
dc.date.available2024-09-18T19:54:19Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: To study the histological changes of the preputial tissue from birth to prepubertal age in order to define unnoticed morphological changes. Materials and Methods: Prepuce samples were obtained from 79 healthy boys who underwent routine ritual circumcision. Specimens were divided into six groups according to the boys' age: newborn, 0-1 year of age, 2-3 years of age, 4-5 years of age, 6-7 years of age, and 8-9 years of age. Histologic analysis of the specimens was performed by H&E, Masson's trichrome, Verhoeff-Von Gieson, immunohistochemical staining. Results: Microscopic examinations showed that average epithelial thickness increased after the neonatal period (p=0.001). When collagen fiber density was evaluated, no significant differences between groups were found (p=0.083). When the elastic fibers in the dermis were evaluated, it was determined that the number and thickness of elastic fibers increased with age. Immunohistochemical examinations showed that the number of peripheral nerves marked with S100 was lower in the neonatal period than at other ages (p=0.048). When the vessels marked with CD105 antibody were counted, there was no significant difference between the groups (p=0.078). Conclusions: This is the first study to examine the age -related structure of connective tissue elements in the foreskin. Our results showed that the prepuce's prepubertal maturation process is continuous, and the first 2 years of life are appropriate not only in relation to the physiological effects of age but also the optimum structural changes for wound healing, such as vessel diameter, epithelium thickness, peripheral nerve count.en_US
dc.description.sponsorshipMersin University Department of Scientific Research Projects [BAP-TF CTB (MK) 2013-3]en_US
dc.description.sponsorshipThis work was supported by Mersin University Department of Scientific Research Projects (project number: BAP-TF CTB (MKC) 2013-3) .en_US
dc.identifier.doi10.4111/icu.20230034
dc.identifier.endpage188en_US
dc.identifier.issn2466-0493
dc.identifier.issn2466-054X
dc.identifier.issue2en_US
dc.identifier.pmid38454828en_US
dc.identifier.scopus2-s2.0-85187534279en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage180en_US
dc.identifier.urihttps://doi.org/10.4111/icu.20230034
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7662
dc.identifier.volume65en_US
dc.identifier.wosWOS:001180593700012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Urological Assocen_US
dc.relation.ispartofInvestigative and Clinical Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAndrogenen_US
dc.subjectForeskinen_US
dc.subjectHypospadiasen_US
dc.subjectImmunohistochemistryen_US
dc.subjectPeripheral nervesen_US
dc.titleHistological and morphological development of the prepuce from birth to prepubertal ageen_US
dc.typeArticleen_US

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