Genotoxic Effects of a Particular Mixture of Acetamiprid and ?-Cypermethrin on Chromosome Aberration, Sister Chromatid Exchange, and Micronucleus Formation in Human Peripheral Blood Lymphocytes

Basit Öğe Kaydı
dc.contributor.authorKocaman, Ayse Yavuz
dc.contributor.authorTopaktas, Mehmet
dc.date.accessioned2024-09-18T19:48:02Z
dc.date.available2024-09-18T19:48:02Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe genotoxic effects of a particular mixture of acetamiprid (Acm, neonicotinoid insecticide) and alpha-cypermethrin (alpha-cyp, pyrethroid insecticide) on human peripheral lymphocytes were examined in vitro by chromosomal aberrations (CAs), sister chromatid exchange (SCE), and micronucleus (MN) tests. The human peripheral lymphocytes were treated with 12.5 + 2.5, 15 + 5, 17.5 + 7.5, and 20 + 10 mu g/mL of Acm+alpha-cyp, respectively, for 24 and 48 h. The mixture of Acm + alpha-cyp induced the CAs and SCEs at all concentrations and treatment times when compared with both the control and solvent control and these increases were concentration-dependent in both treatment times. MN formation was significantly induced at 12.5 + 2.5, 15 + 5, 17.5 + 7.5, mu g/mL of Acm + alpha-cyp when compared with both controls although these increases were not concentration-dependent. Binuclear cells could not be detected sufficiently in the highest concentration of the mixture (20 + 10 mu g/mL) for both the 24- and 48-h treatment times. Mitotic index (MI), proliferation index (PI) and nuclear division index (NDI) significantly decreased because of the cytotoxic and cytostatic effects of the mixture, at all concentrations for two treatment periods. Significant decreases in MI and PI were concentration dependent at both treatment times. The decrease in NDI was also concentration-dependent at 48-h treatment period. In general, Acm + alpha-cyp inhibited nuclear division more than positive control, mitomycin C (MMC) and showed a higher cytostatic effect than MMC. Furthermore, in this article, the results of combined effects of Acm + alpha-cyp were compared with the results of single effects of Acm or alpha-cyp (Kocaman and Topaktas, 2007, 2009, respectively). In conclusion, the particular mixture of Acm + alpha-cyp synergistically induced the genotoxicity/cytotoxicity in human peripheral blood lymphocytes. (C) 2009 Wiley Periodicals, Inc. Environ Toxicol 25: 157-168, 2010.en_US
dc.description.sponsorshipCukurova University Research Fund [FEF2003D20]en_US
dc.description.sponsorshipContract grant sponsor: Cukurova University Research Fund Contract grant number: FEF2003D20en_US
dc.identifier.doi10.1002/tox.20485
dc.identifier.endpage168en_US
dc.identifier.issn1520-4081
dc.identifier.issn1522-7278
dc.identifier.issue2en_US
dc.identifier.pmid19319990en_US
dc.identifier.scopus2-s2.0-77950909717en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://doi.org/10.1002/tox.20485
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7314
dc.identifier.volume25en_US
dc.identifier.wosWOS:000275804800007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEnvironmental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectacetamipriden_US
dc.subjectalpha-cypermethrinen_US
dc.subjectmixture effectsen_US
dc.subjecthuman peripheral lymphocytesen_US
dc.subjectsister chromatid exchangeen_US
dc.subjectchromosome aberrationen_US
dc.subjectmicronucleusen_US
dc.titleGenotoxic Effects of a Particular Mixture of Acetamiprid and ?-Cypermethrin on Chromosome Aberration, Sister Chromatid Exchange, and Micronucleus Formation in Human Peripheral Blood Lymphocytesen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
7314.pdf
Boyut:
145.33 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu