THE OXIDATIVE STRESS AT LUNGS AFTER MENOPAUSE AND THE ANTIOXIDANT EFFECTS OF VITAMIN D, FISH OIL AND EXERCISE IN AN EXPERIMENTAL RAT MODEL

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dc.contributor.authorArslan, Sertac
dc.contributor.authorArslan, Emine
dc.contributor.authorGuney, Guven
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorDemir, Emre
dc.contributor.authorHazar, Hale Uyar
dc.contributor.authorHazar, Fatih
dc.date.accessioned2024-09-18T20:32:45Z
dc.date.available2024-09-18T20:32:45Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractMenopause is the permanent cessation of ovarian follicular activity and the menstrual cycle. There is little physiologic and histologic data concerning the possible effects of menopause on respiratory tract and possible beneficial agents for respiratory tract against the effects of menopause. The rat lungs and trachea have been obtainedfrom young and old rats which were treated with either vitamin D (VitD; 1000IU/kg/week),Fish oil (FO; 0.8 mL/kg/week) or exercise (running 45 minutes/3 times/week) for 12 weeks after one week overiectomy (OVX) followup. Oxidative stress markers found increased at OVX and OVX+E groups. However, oxidative stress marker levels were lower at OVX+E group than OVX group. Vitamin D and fish oil also caused decreased oxidative stress at lung tissue compared to OVX group. OVX group had histological changes such as epithelial desquamation, peribronchial smooth muscle hypertrophy, peribronchial lymphoid follicles, Type 2 pneumocyte hyperplasia; however, none of them was found at exercise group. Ovariectomy caused respiratory system effects in rats. Menopause cause oxidative stress; however, exercise, vitamin D and fish oil have protective effects against oxidative stress at lungs at different quantities. Ovariectomy group has the greatest damage compared to other groups. Exercise is the best protective modality against the effects of menopause at respiratory system.en_US
dc.identifier.endpage11373en_US
dc.identifier.issn1018-4619
dc.identifier.issn1610-2304
dc.identifier.issue12Aen_US
dc.identifier.startpage11363en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11091
dc.identifier.volume29en_US
dc.identifier.wosWOS:000629180800036en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherParlar Scientific Publications (P S P)en_US
dc.relation.ispartofFresenius Environmental Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMenopauseen_US
dc.subjectOxidative Stressen_US
dc.subjectVitamin Den_US
dc.subjectFish Oilen_US
dc.subjectExerciseen_US
dc.titleTHE OXIDATIVE STRESS AT LUNGS AFTER MENOPAUSE AND THE ANTIOXIDANT EFFECTS OF VITAMIN D, FISH OIL AND EXERCISE IN AN EXPERIMENTAL RAT MODELen_US
dc.typeArticleen_US

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