Antipsychotic-like effect of minocycline in a rat model

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dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.authoridErbas, Oytun/0000-0001-5427-8428
dc.authoridDokuyucu, Recep/0000-0001-7881-8871
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorKokacya, Hanifi
dc.contributor.authorInanir, Sema
dc.contributor.authorCopoglu, Umit Sertan
dc.contributor.authorErbas, Oytun
dc.date.accessioned2024-09-18T20:32:53Z
dc.date.available2024-09-18T20:32:53Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: Tetracycline antibiotic drug minocycline has strongly neuroprotective and anti-inflammatory effects. Minocycline has also remarkable brain tissue penetration, is clinically entirely tolerated and properly absorbed when taken orally. In our study, we class with the effects of minocycline and chlorpromazine, a conventional antipsychotic drug, by evaluating the novelty-induced rearing, apomorphine-induced stereotypic behavior, and brain MDA levels in rats. Materials and Methods: Four groups of rat (n = 7) were applied with minocycline (50 and 100 mg/kg, i.p.), chlorpromazine (1 mg/kg, i.p.), or isotonic saline (1 mL/kg, i.p.). One hour later, apomorphine (2 mg/kg, s.c.) was applied to each rat. Result: Our results showed that both doses of minocycline significantly decreased the rearing behavior in rats, whereas the decrease with chlorpromazine was higher. Minocycline also decreased the stereotypy scores in a dose-dependent manner. Conclusion: We concluded that minocycline has beneficial effects on rearing behavior and stereotypy, which are accepted to be indicators of antipsychotic effect. Taken together, minocycline, as an anti-oxidant and cytoprotective agent, can be useful in neuroprotection especially on early stages of psychosis or prepsychotic patients with insignificant symptoms. Minocycline is worthy of being investigated for its anti-psychotic effects as a primary or an adjunctive drug.en_US
dc.identifier.endpage3361en_US
dc.identifier.issn1940-5901
dc.identifier.issue10en_US
dc.identifier.pmid25419368en_US
dc.identifier.scopus2-s2.0-84910026155en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3354en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11191
dc.identifier.volume7en_US
dc.identifier.wosWOS:000345121100026en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMinocyclineen_US
dc.subjectschizophreniaen_US
dc.subjectpsychosisen_US
dc.subjectnovelty-induced rearingen_US
dc.subjectstereotypic behavioren_US
dc.titleAntipsychotic-like effect of minocycline in a rat modelen_US
dc.typeArticleen_US

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