Protective effect of alpha-lipoic acid in methotrexate-induced ovarian oxidative injury and decreased ovarian reserve in rats

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dc.contributor.authorKarapinar, Oya Soylu
dc.contributor.authorPinar, Neslihan
dc.contributor.authorOzcan, Oguzhan
dc.contributor.authorOzgur, Tumay
dc.contributor.authorDolapcioglu, Kenan
dc.date.accessioned2024-09-18T19:52:38Z
dc.date.available2024-09-18T19:52:38Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractTo determine whether the possible oxidative effect of methotrexate (Mtx) on ovary and to evaluate the effectiveness of alpha lipoic acid (ALA), which may be useful in many oxidative stress models.Thirty-two female Wistar-albino rats were randomly divided into four groups; control group, alpha lipoic acid group (ALA 100mg/kg, 10days), multiple dose Mtx group (Mtx 1mg/kg 1, 3, 5, 7days) and Mtx and ALA group (Mtx 1mg/kg 1, 3, 5, 7days and ALA 100mg/kg, 10days). Serum total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI), tumor necrosis factor-alpha (TNF-), tissue malondialdehyde (MDA) and activities of glutathione peroxidase (GSH-Px) and catalase (CAT) and anti-Mullerian hormone (AMH) and total ovarian follicle count were evaluated.Mtx administration caused a significant decrease in TAS, a significant increase in TOS and OSI, a significant increase in MDA levels and a decrease in GSH-Px and CAT activity. Moreover the proinflammatory cytokine (TNF-) was increased in the Mtx group. And AMH values and total follicle count were significantly decreased in Mtx group. However, ALA treatment reversed biochemical results and AMH levels and total follicle count.Alpha lipoic acid ameliorates methotrexate induced oxidative damage of ovarian in rats.en_US
dc.identifier.doi10.1080/09513590.2017.1306847
dc.identifier.endpage659en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue8en_US
dc.identifier.pmid28361557en_US
dc.identifier.scopus2-s2.0-85016508765en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage653en_US
dc.identifier.urihttps://doi.org/10.1080/09513590.2017.1306847
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7573
dc.identifier.volume33en_US
dc.identifier.wosWOS:000411079100016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlpha lipoic aciden_US
dc.subjectmethotrexateen_US
dc.subjectovarian reserveen_US
dc.subjectoxidative stressen_US
dc.titleProtective effect of alpha-lipoic acid in methotrexate-induced ovarian oxidative injury and decreased ovarian reserve in ratsen_US
dc.typeArticleen_US

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