Prognostic Value of Preoperative CEA, CA 19-9, CA 72-4, and AFP Levels in Gastric Cancer

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dc.contributor.authorUcar, Edip
dc.contributor.authorSemerci, Ersan
dc.contributor.authorUstun, Hasan
dc.contributor.authorYetim, Tugba
dc.contributor.authorHuzmeli, Can
dc.contributor.authorGullu, Murat
dc.date.accessioned2024-09-18T19:52:34Z
dc.date.available2024-09-18T19:52:34Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Recent research has suggested that serum tumor markers can give valuable prognostic information in gastric cancer. In this study, we examined the relationship between preoperative serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, CA 72-4, and alfa fetoprotein (AFP) levels on clinicopathologic significance in gastric cancer patients. Methods: Preoperative plasma levels of CEA, CA 19-9, CA 72-4, and AFP were retrospectively examined in 95 patients who underwent surgical resection for gastric cancer, and the prognostic value of the tumour markers were estimated. Results: The percentage of CA 19-9, CA 72-4, CEA, and AFP-positive cases were 41%, 32.6%, 24.2%, and 8.4%, respectively. CEA was more frequently positive in the patients with liver metastases (P=0.02). CA 19-9 was more frequently positive in patients with lymph node (P=0.005), peritoneal (P=0.01), and serosal (P=0.03) involvement. CA 72-4 was more frequently positive in patients with lymph node (P=0.01), peritoneal (P=0.03), and liver (P=0.01) involvement. Low 3-year cumulative survival was associated significantly with elevated serum levels of CEA (P=0.001), CA 19-9 (P=0.001), CA 72-4 (P=0.001), and AFP (P=0.01). In multivariate analysis, age, tumor stage, and CA 72-4 were the only independent prognostic factors. Being positive for CA 72-4 was associated with a 3.8-fold higher risk of death (95% confidence intervals: 1.3, 10.9). Conclusion: Our results suggest that high preoperative serum levels of CA 72-4 in gastric cancer patients are associated with a higher risk of death due to gastric cancer.en_US
dc.identifier.doi10.1007/s12325-008-0100-4
dc.identifier.endpage1084en_US
dc.identifier.issn0741-238X
dc.identifier.issn1865-8652
dc.identifier.issue10en_US
dc.identifier.pmid18821070en_US
dc.identifier.scopus2-s2.0-61749094899en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1075en_US
dc.identifier.urihttps://doi.org/10.1007/s12325-008-0100-4
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7520
dc.identifier.volume25en_US
dc.identifier.wosWOS:000260181700010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAdvances in Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectalfa fetoproteinen_US
dc.subjectCA 19-9en_US
dc.subjectCA 72-4en_US
dc.subjectcarcinoembryonic antigenen_US
dc.subjectgastric canceren_US
dc.titlePrognostic Value of Preoperative CEA, CA 19-9, CA 72-4, and AFP Levels in Gastric Canceren_US
dc.typeArticleen_US

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