Protective effects of caffeic acid phenethyl ester, vitamin C, vitamin E and N-acetylcysteine on vancomycin-induced nephrotoxicity in rats

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dc.authoridGORUR, Sadik/0000-0002-3458-5428
dc.contributor.authorOcak, Sabahattin
dc.contributor.authorGorur, Sadik
dc.contributor.authorHakverdi, Sibel
dc.contributor.authorCelik, Sefa
dc.contributor.authorErdogan, Suat
dc.date.accessioned2024-09-18T21:05:20Z
dc.date.available2024-09-18T21:05:20Z
dc.date.issued2007
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe objective of this study was to compare the beneficial effects of caffeic acid phenethyl ester (CAPE), vitamin C, vitamin E and N-acetylcysteine on vancomycin-induced nephrotoxicity. Thirty rats were randomly devided into six groups: (i) control; (ii) vancomycin, 200 mg/kg administrated via intraperitoneal route; (iii) vancomycin plus CAPE - vancomycin with 10 mu mol/kg CAPE; (iv) vancomycin plus vitamin C - vancomycin (intraperitoneally) with 200 mg/dl vitamin C in drinking water; (iv) vancomycin plus vitamin E - vancomycin with 1000 mg/kg body weight vitamin E (intramuscularly); and (vi) vancomycin plus N-acetylcysteine - vancomycin with 10 mg/kg body weight (intraperitoneally) of N-acetylcysteine. Vancomycin treatments were started I day after the first administrations of these agents and continued for 7 days. At the end of the experiments, catalase activity was significantly decreased by vancomycin in kidney homogenates (P < 0.05). Vitamin E, vitamin C, N-acetylcysteine and CAPE administrations decreased the blood urea nitrogen levels increased by vancomycin, although significant differences were detected only in the vitamins E and C groups (P < 0.05). Increased renal malondialdehyde and nitric oxide levels by vancomycin were significantly suppressed by agents used in the study (P < 0.05). Histopathological examination demonstrated prominent damages in the vancomycin-treated group. Vitamin E was the most beneficial agent on vancomycin-induced tubular damage, followed by vitamin C, N-acetyleysteine and CAPE treatments, respectively. The data suggest that vitamin E, as well as vitamin C, N-acetyleysteine and CAPE, could be useful for reducing the detrimental effects on vancomycin-induced toxicity in kidneys.en_US
dc.identifier.doi10.1111/j.1742-7843.2007.00051.x
dc.identifier.endpage333en_US
dc.identifier.issn1742-7835
dc.identifier.issn1742-7843
dc.identifier.issue5en_US
dc.identifier.pmid17448119en_US
dc.identifier.scopus2-s2.0-34247324695en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage328en_US
dc.identifier.urihttps://doi.org/10.1111/j.1742-7843.2007.00051.x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13521
dc.identifier.volume100en_US
dc.identifier.wosWOS:000246449300007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGentamicin-Induced Nephrotoxicityen_US
dc.subjectTargeting Superoxide-Dismutaseen_US
dc.subjectProximal Tubule Cellsen_US
dc.subjectOxidative Stressen_US
dc.subjectNitric-Oxideen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectRenal Toxicityen_US
dc.subjectCisplatinen_US
dc.subjectSerumen_US
dc.subjectSupplementationen_US
dc.titleProtective effects of caffeic acid phenethyl ester, vitamin C, vitamin E and N-acetylcysteine on vancomycin-induced nephrotoxicity in ratsen_US
dc.typeArticleen_US

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