The Effects of Lung Ischaemia/Reperfusion on TRPM Gene Expression

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dc.authoridDokuyucu, Recep/0000-0001-6837-3477
dc.contributor.authorAtabay, H. D.
dc.contributor.authorDemir, T.
dc.contributor.authorDokuyucu, Recep
dc.contributor.authorYumrutas, O.
dc.contributor.authorOztuzcu, S.
dc.contributor.authorCeribasi, A. O.
dc.contributor.authorBayraktar, R.
dc.date.accessioned2024-09-18T20:29:39Z
dc.date.available2024-09-18T20:29:39Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Transient receptor potential melastatin (TRPM) are integral membrane proteins that have broad range of cellular functions. Roles of TRPM2, TRPM3, TRPM4 and TRPM7 among these channels are very important, and their roles in lung ischaemia/reperfusion injury have not been evaluated yet. The aim of this study is to investigate the contribution of these genes in lung ischaemia/reperfusion injury and evaluate histopathology of tissues. Methods: A total of 40 Wistar albino rats were enrolled for the study. Ischaemia was performed by the application of an atramvatic clamp to pulmonary artery. Gene expressions were determined by the semi-quantitative reverse transcription-polymerase chain reaction method. Histopatholical evaluations were held by a standard haematoxyline-eosin staining. Results: The major histopathological tissue damage was observed in ischaemia performed groups, and expression of TRPM channels was found to be obviously downregulated. Substantial changes were determined between TRPM2, TRPM3, TRPM4 and TRPM7 and lung ischaemia/reperfusion injury. In particular; expression of TRPM2 and TRPM7 was reversibly downregulated in ischaemia. Yet, the expression of TRPM3 and TRPM4 was irreversibly downregulated after ischaemia. Conclusion: Consequently, these results indicate that TRPM family of cation channels may have significant roles in the lung ischaemia/reperfusion injury.en_US
dc.identifier.doi10.7727/WIMJ.2016.334
dc.identifier.endpage331en_US
dc.identifier.issn0043-3144
dc.identifier.issn2309-5830
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85122059210en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage326en_US
dc.identifier.urihttps://doi.org/10.7727/WIMJ.2016.334
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10995
dc.identifier.volume69en_US
dc.identifier.wosWOS:000719641000012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv West Indies Faculty Medical Sciencesen_US
dc.relation.ispartofWest Indian Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLung ischaemia reperfusionen_US
dc.subjecttransient receptor potential channelsen_US
dc.subjectTRPM2/3/4/7en_US
dc.titleThe Effects of Lung Ischaemia/Reperfusion on TRPM Gene Expressionen_US
dc.typeArticleen_US

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