Urotensin II (U-II), a novel cyclic peptide, possibly associated with the pathophysiology of osteoarthritis

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dc.authoridOkuyan, Hamza Malik/0000-0001-7616-3330
dc.contributor.authorGogebakan, Bulent
dc.contributor.authorUruc, Vedat
dc.contributor.authorOzden, Raif
dc.contributor.authorDuman, Ibrahim Gokhan
dc.contributor.authorYagiz, Abdullah Erman
dc.contributor.authorOkuyan, Hamza Malik
dc.contributor.authorAldemir, Ozgur
dc.date.accessioned2024-09-18T21:00:30Z
dc.date.available2024-09-18T21:00:30Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractSynovial fibrosis is one of the main outcomes of osteoarthritis. Some authors have reported that urotensinII (U-II) may cause pathologic fibrosis in cardiovascular system, lung and liver. However there are no previous reports available in the literature about its relationship with the synovial fibrosis in osteoarthritis. The aim of this study was to compare the U-II levels in knee synovial fluids obtained from osteoarthritic and non-osteoarthritic patients. Two groups were created, the osteoarthritis group and non-osteoarthritic control group. The control group was consisted of patients who underwent arthroscopic surgery for other reasons than cartilage disorders. In the osteoarthritis group all patients had grade 4 primer degenerative osteoarthritis and were treated with total knee arthroplasty. Minimum 1 mL knee synovial fluids were obtained during operation. Levels of U-II were measured by using ELISA kit U-II levels were significantly higher in the osteoarthritic group than that in the control group. No correlation was found between U-II levels and age. In conclusion, the significantly high U-II levels in the knee synovial fluid of osteoarthritic patients supported our hypothesis that U-II may be associated with the synovial fibrosis in osteoarthritis.(c) 2014 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.peptides.2014.01.010
dc.identifier.endpage161en_US
dc.identifier.issn0196-9781
dc.identifier.issn1873-5169
dc.identifier.pmid24468547en_US
dc.identifier.scopus2-s2.0-84894536521en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage159en_US
dc.identifier.urihttps://doi.org/10.1016/j.peptides.2014.01.010
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12728
dc.identifier.volume54en_US
dc.identifier.wosWOS:000334508400018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofPeptidesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectUrotensin-IIen_US
dc.subjectSynovial fluiden_US
dc.subjectOsteoarthritisen_US
dc.subjectFibrosisen_US
dc.titleUrotensin II (U-II), a novel cyclic peptide, possibly associated with the pathophysiology of osteoarthritisen_US
dc.typeArticleen_US

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