Cytogenotoxic effects of venlafaxine hydrochloride on cultured human peripheral blood lymphocytes
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Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The potential genotoxic effect of venlafaxine hydrochloride (venlafaxine), an antidepressant drug-active ingredient, was investigated by using in vitro chromosome aberrations (CAs) and cytokinesis-block micronucleus (CBMN) assays in human peripheral blood lymphocytes (PBLs). Mitotic index (MI) and cytokinesis-block proliferation index (CBPI) were also calculated to determine the cytotoxicity of this active drug. For this aim, the human PBLs were treated with 25, 50, and 100 mu g/ml venlafaxine for 24 h and 48 h. The results of this study showed that venlafaxine significantly induced the formation of structural CA and MN for all concentrations (25, 50, and 100 mu g/ml) and treatment periods (24 h and 48 h) when compared with the negative and the solvent control (except 25 mu g/ml at 48 h for MN). In addition, the increases in the percentage of structural CA and MN were concentration-dependent for both treatment times. With regard to cell cycle kinetics, venlafaxine significantly decreased the MI at all concentrations, and also CBPI at the higher concentrations for both treatment times as compared to the control groups. The present results indicate for the first time that venlafaxine had significant clastogenic and cytotoxic effects at the tested concentrations (25, 50, and 100 mu g/ml) in the human PBLs, in vitro; therefore, its excessive and careless use may pose a potential risk to human health.
Açıklama
Anahtar Kelimeler
Venlafaxine hydrochloride, cytogenotoxicity, human peripheral blood lymphocytes, chromosome aberration, micronucleus
Kaynak
Drug and Chemical Toxicology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
43
Sayı
2
