CREB1 and PPAR-?/? Pathways in Hepatic Ischemia/Reperfusion: Route for Curcumin to Hepatoprotection

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dc.authoridDemir, Enver/0000-0002-2620-6192
dc.contributor.authorDemir, Enver Ahmet
dc.contributor.authorTutuk, Okan
dc.contributor.authorDogan-Gocmen, Hatice
dc.contributor.authorOzyilmaz, Duygu Seren
dc.contributor.authorKaragul, Meryem Ilkay
dc.contributor.authorKara, Mikail
dc.contributor.authorTemiz, Muhyittin
dc.date.accessioned2024-09-18T20:13:31Z
dc.date.available2024-09-18T20:13:31Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: Hepatic ischemia/reperfusion injury is a major problem that can exacerbate complications, particularly in liver trans-plantations. Objectives: This study aimed to investigate the cellular mechanisms of ischemia/reperfusion injury and hepatoprotection by cur -cumin. Methods: Wistar albino rats were divided into four groups as Control, Sham, I/R, and Cur+I/R. Hepatic ischemia/reperfusion was induced in I/R and Cur+I/R animals, the latter of which was also given 50 mg/kg/day of curcumin for 14 days. Liver aminotransferases and the transcription regulators of inflammation (RelA, I & kappa;B, PPAR-& alpha;, PPAR-& gamma;, CREB1) were examined along with the histological examination. Results: Hepatic ischemia/reperfusion was found to disrupt hepatic microstructure and downregulate PPAR-& alpha;, PPAR-& gamma;, and CREB1 transcripts. Curcumin supplementation in hepatic ischemia/reperfusion recovered the structural organization and promoted the hepatocyte regeneration while increasing expressions of PPARs and CREB1. RelA and I & kappa;B were found unaltered, possibly due to the crosstalk between targeted transcripts by ischemia/reperfusion and curcumin. Conclusions: In sum, PPAR-& alpha;/& gamma; and CREB1 were involved in hepatic ischemia/reperfusion and, moreover, were detected to be stim-ulated by curcumin. PPAR and CREB pathways were found to provide a route to hepatoprotection for curcumin supplementation as evidenced by the microstructural improvement.en_US
dc.description.sponsorshipScien-tific Research Projects Coordination Unit at Hatay Mustafa Kemal University [17]en_US
dc.description.sponsorshipFunding/Support: This study was granted by the Scien-tific Research Projects Coordination Unit at Hatay Mustafa Kemal University (BAP#17.A.001) .en_US
dc.identifier.doi10.5812/ijpr-133779
dc.identifier.issn1735-0328
dc.identifier.issn1726-6890
dc.identifier.issue1en_US
dc.identifier.pmid36942070en_US
dc.identifier.scopus2-s2.0-85147534453en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.5812/ijpr-133779
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9236
dc.identifier.volume21en_US
dc.identifier.wosWOS:001016346700001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBrieflanden_US
dc.relation.ispartofIranian Journal of Pharmaceutical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCREBen_US
dc.subjectCurcuminen_US
dc.subjectInflammationen_US
dc.subjectIschemiaen_US
dc.subjectReperfusionen_US
dc.subjectLiveren_US
dc.subjectPPARen_US
dc.titleCREB1 and PPAR-?/? Pathways in Hepatic Ischemia/Reperfusion: Route for Curcumin to Hepatoprotectionen_US
dc.typeArticleen_US

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