Inula viscosa ameliorates acetic acid induced ulcerative colitis in rats

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dc.authoridEtyemez, Muhammed/0000-0003-0497-1878
dc.authoridAYDIN, TUBA/0000-0002-7653-6480
dc.authoridUyar, Ahmet/0000-0003-4345-6756
dc.authoridGUVENC, MEHMET/0000-0002-9716-0697
dc.authoridTURK, ERDINC/0000-0003-1735-1774
dc.authoridIsler, Cafer Tayer/0000-0002-1910-8316
dc.authoridGOKCEK, ISHAK/0000-0002-0590-6405
dc.contributor.authorCellat, Mustafa
dc.contributor.authorTekeli, Ibrahim Ozan
dc.contributor.authorTurk, Erdinc
dc.contributor.authorAydin, Tuba
dc.contributor.authorUyar, Ahmet
dc.contributor.authorIsler, Cafer Tayer
dc.contributor.authorGokcek, Ishak
dc.date.accessioned2024-09-18T19:48:02Z
dc.date.available2024-09-18T19:48:02Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIncreased pro-inflammatory cytokines and oxidative stress contribute to the pathophysiology of ulcerative colitis (UC). Inula viscosa is a plant with antioxidant and anti-inflammatory properties. We investigated the effect of an ethanolic extract of I. viscosa on an experimental UC model created using acetic acid. Rats were divided into four groups of eight: group 1, control; group 2, 3% acetic acid group; group 3, 100 mg/kg sulfasalazine + 3% acetic acid group; group 4, 400 mg/kg I. viscosa + 3% acetic acid. I. viscosa and sulfasalazine were administered by oral gavage and 3% acetic acid was administered per rectum. We found that I. viscosa treatment decreased colon malondialdehyde, tumor necrosis factor-alpha, interleukin-1 beta and nuclear factor kappa B levels; it increased reduced glutathione, nuclear factor erythroid 2-related factor 2, heme oxygenase-1 and kelch-like ECH-associated protein 1 levels and glutathione peroxidase enzyme activity. Group 1 colon exhibited normal histological structure. Slight inflammatory cell infiltration and edema and insignificant slight erosion in crypts were detected in colon tissues of group 4. We found that I. viscosa reduced oxidative stress and inflammation, which was protective against UC by inducing the Nrf-2/Keap-1/HO-1 pathway in the colon.en_US
dc.description.sponsorshipScientific Research Projects Coordination of Hatay Mustafa Kemal University [19.M.011]en_US
dc.description.sponsorshipThis study was supported financially by the Scientific Research Projects Coordination of Hatay Mustafa Kemal University, project no. 19.M.011.en_US
dc.identifier.doi10.1080/10520295.2023.2176923
dc.identifier.endpage266en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue4en_US
dc.identifier.pmid37165766en_US
dc.identifier.startpage255en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2023.2176923
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7315
dc.identifier.volume98en_US
dc.identifier.wosWOS:000936363600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetic aciden_US
dc.subjectantioxidanten_US
dc.subjectinflammationen_US
dc.subjectInula viscosaen_US
dc.subjectratsen_US
dc.subjectulcerative colitisen_US
dc.titleInula viscosa ameliorates acetic acid induced ulcerative colitis in ratsen_US
dc.typeArticleen_US

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