Biochemical and Histopathological Examination of the Effect of Cigarette Smoking on Rat Kidneys

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dc.contributor.authorDonder, Ahmet
dc.contributor.authorBalahoroglu, Ragip
dc.contributor.authorDulger, Haluk
dc.contributor.authorSekeroglu, Mehmet Ramazan
dc.contributor.authorYilmaz, Ahmet
dc.contributor.authorAslanhan, Hamza
dc.contributor.authorDeveci, Senay
dc.date.accessioned2024-09-18T20:11:27Z
dc.date.available2024-09-18T20:11:27Z
dc.date.issued2017
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractOBJECTIVE: To study the negative effects of cigarette smoke on the kidney, and to determine if those effects are reversed after smoking cessation. STUDY DESIGN: A total of 40 rats were divided into 5 groups of 8 each: group I, control group; group II, rats exposed to cigarette smoke; group III, rats that discontinued smoking for 1 month; group IV, rats that discontinued smoking for 3 months; and group V, rats that discontinued smoking for 5 months. Serum urea, creatinine, cotinine, IL-18, NGAL, and KIM-1 levels were measured in the blood samples. RESULTS: Cotinine levels in all groups were similar to those of the control group, but only the nicotine group had a significant increase. The active smoker group exposed to cigarette smoke displayed dense vacuolization. As a result of the exposure to cigarette smoke, increasing levels of urinary creatine, microalbumin, and beta-2 microglobulin and urea in serum led to changes in KIM-1 and NGAL values, which result in dysfunction of glomeruli and tubules. CONCLUSION: We observed that smoking cessation may lead to improvement after 3 months in both biochemical parameters and glomerular and tubular changes and approaches their normal values/structures 5 months later.en_US
dc.description.sponsorshipYuzuncu Yil University Scientific Research Projects Directorate, Van, Turkeyen_US
dc.description.sponsorshipSupported by the Yuzuncu Yil University Scientific Research Projects Directorate, Van, Turkey.en_US
dc.identifier.endpage222en_US
dc.identifier.issn0884-6812
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85028359243en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage215en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8851
dc.identifier.volume39en_US
dc.identifier.wosWOS:000422943600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcigarette smokeen_US
dc.subjecthistopathologyen_US
dc.subjectIL-18en_US
dc.subjectkidneyen_US
dc.subjectKIM-1en_US
dc.subjectNGAL proteinen_US
dc.subjectnicotineen_US
dc.subjectrenal damageen_US
dc.subjectrenal diseaseen_US
dc.subjectsmokingen_US
dc.subjecttobacco smokingen_US
dc.titleBiochemical and Histopathological Examination of the Effect of Cigarette Smoking on Rat Kidneysen_US
dc.typeArticleen_US

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