Humulane and Germacrane Sesquiterpenes from Ferula lycia

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Date

2010

Journal Title

Journal ISSN

Volume Title

Publisher

Amer Chemical Soc

Access Rights

info:eu-repo/semantics/closedAccess

Abstract

Five new juniferol esters (1-5), along with six known humulane derivatives (6-11), were isolated from the roots of Ferula lycia, an endemic Turkish species. The fruits of the same species were also investigated and led to the isolation of these same compounds, as well as two known germacrane esters (12 and 13). All isolated sesquiterpenes were assayed for cytotoxicity against two tyrosine kinase inhibitor-resistant cell lines, K562R and DA1-3b/M2(BCR-ABL). The two most active compounds, juniferinin (7) and 6-beta-p-hydroxybenzoyloxygermacra-1(10),4-diene (12), were moderately active against Raji lymphoma cells but also displayed some toxicity against healthy bone marrow cells.

Description

Keywords

Daucane, Esters

Journal or Series

Journal of Natural Products

WoS Q Value

Q1

Scopus Q Value

Q1

Volume

73

Issue

4

Citation