MicroRNA 211 expression is upregulated and associated with poor prognosis in colorectal cancer: a case-control study

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dc.authoridSumbul, Ahmet Taner/0000-0002-5573-906X
dc.authoridBayram, Suleyman/0000-0002-7087-8615
dc.contributor.authorSumbul, Ahmet Taner
dc.contributor.authorGogebakan, Bulent
dc.contributor.authorBayram, Suleyman
dc.contributor.authorBatmaci, Celal Yucel
dc.contributor.authorOztuzcu, Serdar
dc.date.accessioned2024-09-18T20:11:37Z
dc.date.available2024-09-18T20:11:37Z
dc.date.issued2015
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIncreasingly more evidence support the role of the microRNAs (miRNA) in tumorigenesis. The role of up/downregulation microRNA-211 (miR-211) during human tumorigenesis is still contentious and may exhibit tissue-specific regulatory manner, but the exhaustive mechanisms underlying its pro/anti-oncogenic effects remain to be unknown. Sixty-six patients that were diagnosed and operated with colorectal cancer (CRC) and sixty-five healthy cases that were age and sex compatible with them were included in our study. miRNA was isolated from the formalin-fixed paraffin-embedded (FFPE) tissues of all cases. The expression level of miR-211 in matched normal and tumor tissues of CRC group and healthy group was evaluated using a quantitative real-time RT-PCR (qRT-PCR). Based on the average miR-211 levels, two groups of low or high expression were formed in CRC group. Correlation of the patients' clinicopathological factors and survival was also analyzed. No statistically significant differences were found in miR-211 levels among tumorous and normal tissues of CRC patient group (P = 0.59). Also, no statistically significant correlation was determined between clinicopathological factors and miR-211 expression level in CRC group. However, miR-211 expression levels between the CRC group and the healthy group were determined to be of statistical significance (P < 0.0001). There were 33 (50 %) CRC patients that expressed low levels of miR-211 and 33 (50 %) CRC patients that expressed high levels of miR-211. A median survival between low levels of miR-211 group and high levels of miR-211 group was evaluated via Kaplan-Meier, and the difference was of statistical significance (P = 0.035). The univariate analysis of the factors that may affect survival indicated invasion depth (P = 0.063), lymphovascular invasion (P = 0.011), perineural invasion (P = 0.009), and miR-211 expression level (P = 0.041) presence to be effective. In the multivariate analysis of these factors with overall survival, only miR-211 expression level (P = 0.01) was effective on overall survival. Our results suggest for the first time that miR-211 expressed more in CRC patients than in healthy group could be a new prognostic biomarker in order to predict survival. Independent studies are needed to validate our findings in a larger series, as well as in cancer of different tissues.en_US
dc.description.sponsorshipTurkish Medical Oncology Societyen_US
dc.description.sponsorshipThis study was performed with a grant taken from the Turkish Medical Oncology Society.en_US
dc.identifier.doi10.1007/s13277-015-3708-4
dc.identifier.endpage9709en_US
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.issue12en_US
dc.identifier.pmid26152286en_US
dc.identifier.scopus2-s2.0-84952870613en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage9703en_US
dc.identifier.urihttps://doi.org/10.1007/s13277-015-3708-4
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8978
dc.identifier.volume36en_US
dc.identifier.wosWOS:000367329300066en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofTumor Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectColorectal canceren_US
dc.subjectmicroRNAen_US
dc.subjectmiR-211en_US
dc.subjectBiomarkeren_US
dc.titleMicroRNA 211 expression is upregulated and associated with poor prognosis in colorectal cancer: a case-control studyen_US
dc.typeArticleen_US

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