Antioxidant effects of vitamin D on lacrimal glands against high dose radioiodine-associated damage in an animal model

Basit Öğe Kaydı
dc.authoridyakin, mehmet/0000-0002-3470-4124
dc.authoridDemir, Ayten/0000-0002-5677-2347
dc.authoridEksioglu, Umit/0000-0002-3061-7162
dc.authoridAribal Ayral, Pelin/0000-0002-5047-7881
dc.authoridYazihan, Nuray/0000-0003-1237-8468
dc.authoridaltiparmak, ugur/0000-0002-3262-5959
dc.contributor.authorEksioglu, Umit
dc.contributor.authorAtilgan, Hasan Ikbal
dc.contributor.authorYakin, Mehmet
dc.contributor.authorYazihan, Nuray
dc.contributor.authorAltiparmak, Ugur Emrah
dc.contributor.authorYumusak, Nihat
dc.contributor.authorKorkmaz, Meliha
dc.date.accessioned2024-09-18T20:55:37Z
dc.date.available2024-09-18T20:55:37Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose: To evaluate antioxidant effects of active vitamin D (calcitriol) against high-dose radioiodine (RAI) therapy-associated damage of lacrimal gland. Materials and methods: Wistar albino rats were used and divided into three groups randomly (n = 12/group). The first group was appointed as the negative control group and received no RAI or medication. The second group was appointed as the positive control group that only received 3 mCi/kg (111 MBq/kg) RAI via gastric gavage and the last group was the treatment group that received 3 mCi/kg RAI via same method and calcitriol (200 ng/kg/day) via intraperitoneal administration. Seven days after RAI administration, bilateral intraorbital (IG), extraorbital (EG) and Harderian (HG) glands were removed for the evaluations of histopathologic, tissue cytokine, total oxidant status (TOS) and total antioxidant status (TAS). Results: RAI led to significant increase in tissue TOS, TNF-alpha, IL-6 levels and significant decrease in IL-10 and TAS levels (p < 0.05 for each). Addition of adjunctive calcitriol reversed all these parameters significantly (p < 0.05 for each).The following histopathologic parameters were seen more frequently in positive control group than the other groups: Abnormal lobular pattern, perivascular infiltration, periductal infiltration, lipofuscin-like accumulation, acinar atrophy, periductal and periacinar fibrosis in all lacrimal gland types (p < 0.05), acinar fibrosis in EG (p = 0.049), periductal fibrosis in EG and HG (p = 0.049 and 0.038, respectively), abnormal cell outlines in EG and HG (p = 0.020 and 0.011, respectively) and variation in cell size in the IG and the HG (p = 0.003 and 0.049 respectively). Conclusions: RAI caused significant oxidative stress and inflammation in lacrimal glands. Vitamin D demonstrated potent anti-inflammatory, antioxidant and radio-protective effects on lacrimal glands in histopathologic, tissue cytokine and oxidant/antioxidant level evaluations.en_US
dc.description.sponsorshipAnkara Branch of Turkish Ophthalmological Associationen_US
dc.description.sponsorshipThis study was financially supported by the Ankara Branch of Turkish Ophthalmological Association.en_US
dc.identifier.doi10.1080/15569527.2018.1498507
dc.identifier.endpage24en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue1en_US
dc.identifier.pmid30003810en_US
dc.identifier.scopus2-s2.0-85053382997en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage18en_US
dc.identifier.urihttps://doi.org/10.1080/15569527.2018.1498507
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11957
dc.identifier.volume38en_US
dc.identifier.wosWOS:000457026400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofCutaneous and Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadioactive iodineen_US
dc.subjectdry eyeen_US
dc.subjectlacrimal glanden_US
dc.subjectvitamin Den_US
dc.subjectradioprotectionen_US
dc.titleAntioxidant effects of vitamin D on lacrimal glands against high dose radioiodine-associated damage in an animal modelen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ N/A ]
İsim:
Tam Metin / Full Text
Boyut:
673.25 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu