The effects of a single dialysis session on serum hepcidin levels

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dc.authoridoguzman, hamdi/0000-0003-1412-7689
dc.contributor.authorOguzman, Hamdi
dc.contributor.authorTekce, Buket Kin
dc.contributor.authorTekce, Hikmet
dc.contributor.authorBugdayci, Guler
dc.date.accessioned2024-09-18T19:54:20Z
dc.date.available2024-09-18T19:54:20Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives Hepcidin plays an important role in regulating iron metabolism. Elevated levels of hepcidin in renal failure contribute to the development of anemia. We aimed to evaluate the association between hepcidin and inflammation in hemodialysis patients and how dialysis affects hepcidin levels.Methods Hepcidin clearance with hemodialysis was investigated by measuring hepcidin concentrations by enzyme-linked immunosorbent assay (ELISA) method before and after hemodialysis of 40 patients in a single dialysis session. Hemogram parameters and ferritin, iron, total iron binding capacity (TIBC), and C-reactive protein (CRP) were measured and evaluated their relations with predialysis hepcidin levels.Results Hepcidin levels decreased significantly with dialysis treatment (p=0.009). Median hepcidin concentration before dialysis was measured as 330 ng/mL (83-459) and post-dialysis median hepcidin concentration was 250 ng/mL (94-384). There was a significant correlation between predialysis hepcidin levels and ferritin (r=0.858, p<0.001), TIBC (r=-0.451, p=0.004), and MCV (r=0.384, p=0.016). It was found that increases in ferritin levels in time were positively correlated with hepcidin before dialysis.Conclusions We think that understanding the removal of the hepcidin by dialysis, which causes a decrease in the amount of iron available in the anemia, is important in managing future therapy.en_US
dc.description.sponsorshipBoluAbant Izzet Baysal University Research Foundation; [2017.08.04.1179]en_US
dc.description.sponsorshipThis study was supported by BoluAbant Izzet Baysal University Research Foundation(no. 2017.08.04.1179)en_US
dc.identifier.doi10.1515/tjb-2023-0009
dc.identifier.endpage70en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85187938316en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage64en_US
dc.identifier.urihttps://doi.org/10.1515/tjb-2023-0009
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7667
dc.identifier.volume49en_US
dc.identifier.wosWOS:001070025000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectanemiaen_US
dc.subjectferritinen_US
dc.subjecthemodialysisen_US
dc.subjecthepcidinen_US
dc.subjectiron deficiencyen_US
dc.titleThe effects of a single dialysis session on serum hepcidin levelsen_US
dc.typeArticleen_US

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