Effects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction sockets

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dc.contributor.authorGunay, Ahmet
dc.contributor.authorArpag, Osman Fatih
dc.contributor.authorAtilgan, Serhat
dc.contributor.authorYaman, Ferhan
dc.contributor.authorAtalay, Yusuf
dc.contributor.authorAcikan, Izzet
dc.date.accessioned2024-09-18T20:06:21Z
dc.date.available2024-09-18T20:06:21Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAim: The purpose of this study was to evaluate the effects of caffeic acid phenethyl ester (CAPE) on palatal mucosal defects and tooth extraction sockets in an experimental model. Materials and methods: Forty-two male Sprague-Dawley rats with a mean age of 7 weeks and weighing 280-490 g were used in this study. The rats were randomly divided into two groups: group A (the control group, n=21) and group B (the experimental group, n=21). Under anesthesia with ketamine (8 mg/100 g, intraperitoneally), palatal mucosal defects were created and tooth extraction was performed in the rats in groups A and B. Group A received no treatment, whereas group B received CAPE. CAPE was injected daily (10 mu mol/kg, intraperitoneally). The rats were killed on days 7, 14, and 30 after the procedures. Palatal mucosa healing and changes in bone tissue and fibrous tissue were evaluated histopathologically. Result: Pairwise comparisons showed no statistically significant difference between days 7 and 14 in either group (P>0.05). At day 30, bone healing was significantly better in group B (CAPE) than in group A (control) (P<0.05). Fibrinogen levels at day 30 were significantly higher in group A (control) than in group B (CAPE) (P<0.05). Pairwise comparisons showed no statistically significant difference in palatal mucosa healing levels between days 7 and 14 in both groups (P>0.05). Conclusion: In conclusion, the findings of this study suggest that CAPE can significantly improve tooth socket healing.en_US
dc.identifier.doi10.2147/DDDT.S67623
dc.identifier.endpage2074en_US
dc.identifier.issn1177-8881
dc.identifier.pmid25364232en_US
dc.identifier.scopus2-s2.0-84908298192en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2069en_US
dc.identifier.urihttps://doi.org/10.2147/DDDT.S67623
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8479
dc.identifier.volume8en_US
dc.identifier.wosWOS:000343404500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofDrug Design Development and Therapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcaffeic acid phenyl esteren_US
dc.subjectpalatal mucosaen_US
dc.subjecttooth extraction socketen_US
dc.subjecthealingen_US
dc.titleEffects of caffeic acid phenethyl ester on palatal mucosal defects and tooth extraction socketsen_US
dc.typeArticleen_US

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