Reduction of hepatorenal and pancreatic damage by Ferula elaeochytris extract in STZ induced diabetic rats

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dc.authoridDemir, Abdulbaki/0000-0002-6867-4410
dc.authoridUyar, Ahmet/0000-0003-4345-6756
dc.authoridYENER, Zabit/0000-0002-6365-5843
dc.contributor.authorUyar, Ahmet
dc.contributor.authorYaman, Turan
dc.contributor.authorKeles, Omer Faruk
dc.contributor.authorAlkan, Elif Ebru
dc.contributor.authorDemir, Abdulbaki
dc.contributor.authorCelik, Ismail
dc.contributor.authorYener, Zabit
dc.date.accessioned2024-09-18T19:54:30Z
dc.date.available2024-09-18T19:54:30Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe therapeutic potential and antioxidant capacity of Ferula elaeochytris extract (FE) in the liver, kidney and pancreas of rats with diabetes induced by streptozotocin (STZ) was assessed using biochemistry, histopathology and immunohistochemistry. Forty adult Wistar albino male rats were divided randomly into five groups of eight rats each. The normal control (NC) group was untreated. The diabetes control (DC) group was treated with STZ to induce diabetes. The diabetes + acarbose group (DAC) was treated with STZ, then with acarbose daily for 28 days. The diabetes + FE (DFE) group was treated with STZ, then FE daily for 28 days. DC rats had inflammatory cell infiltration, hydropic degeneration and necrosis, whereas the DFE rats exhibited nearly normal histology. Insulin immunostaining in the pancreatic beta cells was decreased in the DC group compared to the NC group, whereas the DFE group was similar to the NC group. Many serum biomarkers of damage to liver, kidneys or pancreas were elevated in the DC group compared to the NC group; these biomarkers were decreased in the DFE group. The DC group exhibited increased malondialdehyde levels and decreased levels of the antioxidant defense system constituents compared to the NC group. The level of biomarkers the DFE group was close to the NC group. FE exhibited a protective effect against tissue damage owing to its antioxidant activities and to its ability to effect regeneration of beta-cells in STZ induced diabetic rats.en_US
dc.identifier.doi10.1080/10520295.2020.1753239
dc.identifier.endpage40en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue1en_US
dc.identifier.pmid32396744en_US
dc.identifier.scopus2-s2.0-85084826661en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage28en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2020.1753239
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7769
dc.identifier.volume96en_US
dc.identifier.wosWOS:000533747800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntidiabetic effecten_US
dc.subjectdiabetesen_US
dc.subjectFerula elaeochytrisen_US
dc.subjectkidney damageen_US
dc.subjectliver damageen_US
dc.subjectpancreatic damageen_US
dc.titleReduction of hepatorenal and pancreatic damage by Ferula elaeochytris extract in STZ induced diabetic ratsen_US
dc.typeArticleen_US

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