Characteristics of Hepatocellular Carcinoma Aggressiveness Factors in Turkish Patients

Basit Öğe Kaydı
dc.authoridEKIN, NAZIM/0000-0001-5302-8953
dc.authoridSonsuz, Abdullah/0000-0002-8336-5472
dc.authoridAkkiz, Hikmet/0000-0001-9745-8875
dc.authoridALTINTAS, ENGIN/0000-0003-0796-1456
dc.authoridTokmak, Salih/0000-0002-2727-5632
dc.contributor.authorAkkiz, Hikmet
dc.contributor.authorCarr, Brian I.
dc.contributor.authorYalcin, Kendal K.
dc.contributor.authorGuerra, Vito
dc.contributor.authorKuran, Sedef
dc.contributor.authorAltintas, Engin
dc.contributor.authorUskudar, Oguz
dc.date.accessioned2024-09-18T19:52:33Z
dc.date.available2024-09-18T19:52:33Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractA large cohort of hepatocellular carcinoma (HCC) patients from several collaborating Turkish institutions were examined for the tumor parameters of maximum diameter (MTD), portal vein thrombosis (PVT), and alpha-fetoprotein (AFP) levels. A relationship was found between MTD and blood platelet levels. Patients with large >= 5 cm tumors who had normal platelet levels had significantly larger tumors, higher percent of PVT, and significantly lower blood total bilirubin and liver cirrhosis than similar >= 5 cm tumor patients having thrombocytopenia. A comparison of patients with and without PVT showed significantly larger tumors, greater multifocality, blood AFP, and C-reactive protein levels, and, interestingly, lower HDL levels in the patients with PVT. Fifty-eight percent of the total cohort had AFP levels <= 100 IU/mL ( and 42.1% had values <= 20 IU/mL). These patients had significantly smaller tumors, less tumor multifocality and percent PVT, lower total bilirubin, and less cirrhosis. There was considerable geographic heterogeneity within Turkey in the patterns of HCC presentation, with areas of higher and lower hepatitis B virus, hepatitis D virus, cirrhosis, and tumor aggressiveness parameters. Turkish patients thus have distinct patterns of presentation, but the biological relationships between MTD and both platelets and bilirubin levels are similar to the relationships that have been reported in other ethnic patient groups. (C) 2017 S. Karger AG, Baselen_US
dc.description.sponsorshipNIH [CA 82723]en_US
dc.description.sponsorshipThis work was supported in part by NIH grant CA 82723 (B.I.C.).en_US
dc.identifier.doi10.1159/000484564
dc.identifier.endpage124en_US
dc.identifier.issn0030-2414
dc.identifier.issn1423-0232
dc.identifier.issue2en_US
dc.identifier.pmid29207378en_US
dc.identifier.scopus2-s2.0-85037328025en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage116en_US
dc.identifier.urihttps://doi.org/10.1159/000484564
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7515
dc.identifier.volume94en_US
dc.identifier.wosWOS:000424018500008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlbuminen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectTurkeyen_US
dc.subjectalpha-Fetoproteinen_US
dc.subjectTumor massen_US
dc.subjectAggressivenessen_US
dc.titleCharacteristics of Hepatocellular Carcinoma Aggressiveness Factors in Turkish Patientsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
7515.pdf
Boyut:
488.48 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu