Time-dependent variations in plasma D-dimer levels and biochemical parameters in acute mesenteric ischemia: An experimental study

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dc.authorscopusid57194619849
dc.authorscopusid8336280500
dc.authorscopusid8988852800
dc.authorscopusid25030483100
dc.authorscopusid57214705213
dc.authorscopusid6507797287
dc.contributor.authorYi?it, Yilmaz
dc.contributor.authorYetim, Ibrahim
dc.contributor.authorAydo?an, Akin
dc.contributor.authorÖzkan, Orhan Veli
dc.contributor.authorKoç, Ahmet
dc.contributor.authorYönden, Zafer
dc.date.accessioned2024-09-19T15:41:24Z
dc.date.available2024-09-19T15:41:24Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAcute mesenteric ischemia is a pathology leading to acute abdomen with a very poor prognosis when there is a delay in diagnosis. In this study we aimed to investigate the importance of D-dimer levels and biochemical parameters in early diagnosis of acute mesentheric ischemia by assessing time-dependent variations of these parameters. Forty Wistar-Albino male rats were divided into four groups. Only laparotomy and mesenteric arterial dissection were made in the control group. In the other groups laparotomy was performed, and ischemia was constituted for 2, 4 and 6 hours by ligating mesenteric artery. Blood samples were taken for measuring serum levels of D-dimer and biochemical parameters in rats. Intestinal tissue samples were obtained from ileum to assess the level of ischemia in histopathological examination. There were significant differences between the control and 2-, 4- and 6-hour ischemia groups regarding D-dimer levels and biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, lactic dehydrogenase, creatine phosphokinase and phosphate (p<0.05). There was no statistically signifant difference with respect to alkaline phosphatase levels (p>0.05). D-dimer levels and biochemical parameters increased in correlation with the duration of ischemia, and there were significant differences between the groups (p<0.05). A significantly deeper ichemic injury was observed in correlation with the duration of ischemia in histopathologic examination. Measurement of D-dimer levels and some biochemical parameters studied in this study may be useful in the early diagnosis of acute mesenteric ischemia provided that our findings are supported with further clinical and experimental studies. © Gülhane Askeri Ti{dotless}p Akademisi 2012.en_US
dc.identifier.endpage34en_US
dc.identifier.issn1302-0471
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84859819718en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14244
dc.identifier.volume54en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherGulhane Medical School, University of Health Sciencesen_US
dc.relation.ispartofGulhane Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute mesenteric ischemiaen_US
dc.subjectBiochemical parametersen_US
dc.subjectD-dimeren_US
dc.subjectEarly diagnosisen_US
dc.titleTime-dependent variations in plasma D-dimer levels and biochemical parameters in acute mesenteric ischemia: An experimental studyen_US
dc.title.alternativeAkut mezenter iskemide plazma D-dimer düzeyleri ve biyokimyasal parametrelerin zamana ba?li de?işimi: Deneysel çalişmaen_US
dc.typeArticleen_US

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