The influencer effect of Dexmedetomidine on radioiodine relevant to lacrimal gland impairment

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dc.authoridYazihan, Nuray/0000-0003-1237-8468
dc.authoridBURCU, AYSE/0000-0002-2345-0456
dc.authoridKoca, Gokhan/0000-0003-2842-9223
dc.contributor.authorSingar, Evin
dc.contributor.authorAkbulut, Aylin
dc.contributor.authorKoca, Goekhan
dc.contributor.authorYazihan, Nuray
dc.contributor.authorAtilgan, Hasan Ikbal
dc.contributor.authorYumusak, Nihat
dc.contributor.authorDemir, Ayten
dc.date.accessioned2024-09-18T20:55:38Z
dc.date.available2024-09-18T20:55:38Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurposeTo assess the potential influencing effects of Dexmedetomidine on impaired lacrimal glands after high-dose radioiodine treatment (RAI). MethodsThirty-six rats were arbitrarily separated into 3 groups: Sham, RAI, and Dexmedetomidine. Dexmedetomidine group was given Dexmedetomidine and RAI, the Sham group was given the same millimeters of saline, and the RAI group was given RAI only. All forms of lacrimal glands, including harderian glands (HG), extraorbital (EG), and intraorbital (IG) lacrimal glands, were evaluated for immunohistochemical, histopathologic assessments and also for tissue cytokines, oxidant and antioxidant levels. ResultsDexmedetomidine significantly ameliorated histopathologic changes such as periacinar fibrosis, acinar atrophy, lymphocytic infiltration, ductal proliferation, lipofuscin-like accumulation, and nucleus changes caused by RAI in all lacrimal gland forms (p < 0.05 for all of the parameters). However, periductal fibrosis was improved significantly only in EG (p = 0.049), and mast cell infiltration was improved significantly only in IG (p = 0.038) in Dexmedetomidine groups. There was a significant decrease in the elevated caspase-3 and TUNEL levels after RAI administration in the Dexmedetomidine group in all lacrimal gland forms (p < 0.05 for all parameters). Dexmedetomidine attenuated NF-kb, TNF-alpha, and IL-6 levels significantly diminished total oxidant status and raised total antioxidant status levels (p < 0.05 for all parameters). ConclusionsThe results of this study demonstrated that following RAI, Dexmedetomidine diminished inflammation, tissue cytokine levels, and apoptosis and ameliorated impaired histopathologic patterns of the lacrimal glands.en_US
dc.identifier.doi10.1007/s10792-024-03052-6
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue1en_US
dc.identifier.pmid38411703en_US
dc.identifier.scopus2-s2.0-85186200055en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s10792-024-03052-6
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11966
dc.identifier.volume44en_US
dc.identifier.wosWOS:001171807100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRadioprotectionen_US
dc.subjectDexmedetomidineen_US
dc.subjectLacrimal gland impairmenten_US
dc.subjectRadioiodineen_US
dc.titleThe influencer effect of Dexmedetomidine on radioiodine relevant to lacrimal gland impairmenten_US
dc.typeArticleen_US

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