Hesperidin alleviates inflammation in the metabolic syndrome model

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dc.contributor.authorKazak, Filiz
dc.contributor.authorYarim, Gul Fatma
dc.contributor.authorAnadol, Elvan
dc.contributor.authorSalt, Ayris
dc.date.accessioned2024-09-18T20:14:59Z
dc.date.available2024-09-18T20:14:59Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIn metabolic syndrome, activated inflammatory signaling pathways trigger the release of proinflammatory cytokines. Nowadays, the use of natural bioactive compounds is trending as an alternative method for the treatment and management of metabolic syndrome. This study aimed to assess the potential effects of hesperidin in the metabolic syndrome model by analyzing the proinflammatory and anti-inflammatory cytokines in serum and liver. Rats were divided into 4 groups: Control (Rats were fed a standard chow diet and water ad libitum), hesperidin [Rats were fed hesperidin supplemented standard chow diet (1%, 10 g/kg feed) and water ad libitum] metabolic syndrome (Rats were fed standard chow diet with 10% fructose-added-drinking-water), and metabolic syndrome + hesperidin (Rats were fed a hesperidin-added standard chow diet (1%, 10 g/kg) with 10% fructose-added-drinking-water). Rats were sacrificed under ketamine/xylazine anesthesia, blood was obtained and liver tissues were removed. Tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, interleukin-10, and transforming growth factor-beta in the serum and liver were measured by enzyme-linked immunosorbent assay. In the metabolic syndrome group, higher tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6, but lower serum and liver interleukin-10 and transforming growth factor-beta were found in the serum and liver compared to the control group. In addition, in the metabolic syndrome + factor-beta were found in the serum and liver compared to the metabolic syndrome groups. Consequently, hesperidin response in the metabolic syndrome rat model.en_US
dc.description.sponsorshipOndokuz Mayis University Scientific Research Projects Unit [PYO.VET.1901.17.015]en_US
dc.description.sponsorshipThe research was funded by Ondokuz Mayis University Scientific Research Projects Unit (PYO.VET.1901.17.015) . The abstract of this study has been presented as an oral presentation in the International Asian Congress on Contemporary Sciences -VI, May 27-29, 2022.en_US
dc.identifier.doi10.24099/vet.arhiv.2025
dc.identifier.endpage76en_US
dc.identifier.issn0372-5480
dc.identifier.issn1331-8055
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85190978498en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://doi.org/10.24099/vet.arhiv.2025
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9358
dc.identifier.volume94en_US
dc.identifier.wosWOS:001167998500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Zagreb Vet Facultyen_US
dc.relation.ispartofVeterinarski Arhiven_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcytokineen_US
dc.subjecthesperidinen_US
dc.subjectinsulin resistance syndromeen_US
dc.subjectliveren_US
dc.subjectraten_US
dc.titleHesperidin alleviates inflammation in the metabolic syndrome modelen_US
dc.typeArticleen_US

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