Apigenin alleviates neuroinflammation in a mouse model of Parkinson's disease

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dc.authoridKazak, Filiz/0000-0002-9065-394X
dc.authorid/0000-0002-0636-4214
dc.authoridSozmen, Mahmut/0000-0001-7976-4051
dc.contributor.authorYarim, Gul Fatma
dc.contributor.authorKazak, Filiz
dc.contributor.authorYarim, Murat
dc.contributor.authorSozmen, Mahmut
dc.contributor.authorGenc, Bugra
dc.contributor.authorErtekin, Ali
dc.contributor.authorGokceoglu, Ayris
dc.date.accessioned2024-09-18T20:02:33Z
dc.date.available2024-09-18T20:02:33Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose of the study The aim of this study is to evaluate the effect of apigenin on inflammatory response in brain tissue in Parkinson's mouse model. Materials and methods Parkinson's disease model was induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Sixty 8-10-weeks-old male C57BL/6 mice were randomly divided into four groups control, Parkinson, prophylaxis, and treatment. Control (0.9% NaCl 0.5 ml, 10 days, i.p.), Parkinson (25 mg/kg MPTP, 5 days, i.p.), prophylaxis (50 mg/kg apigenin, 5 days + 25 mg/kg MPTP, 5 days, i.p.), and treatment (25 mg/kg MPTP, 5 days + 50 mg/kg apigenin, 5 days). The expressions and protein levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1-beta (IL-1 beta), IL-6, IL-10, and transforming growth factor-beta (TGF-beta) were determined using immunohistochemistry and enzyme-linked immunosorbent analysis. Results Apigenin administration attenuated MPTP-induced histopathological changes in brain tissue. Furthermore, apigenin reversed the changes in expressions and concentrations of TNF-alpha, IL-1 beta, IL-6, IL-10, and TGF-beta. Conclusion This study suggests that apigenin could be used as a neuroprotective option to attenuate neuroinflammation in Parkinson's disease.en_US
dc.description.sponsorshipTUBITA K (ARDEB, TOVAG) [115O005]en_US
dc.description.sponsorshipThis study was supported by the TUBITA K (ARDEB, TOVAG) with project number 115O005.en_US
dc.identifier.doi10.1080/00207454.2022.2089136
dc.identifier.issn0020-7454
dc.identifier.issn1563-5279
dc.identifier.pmid35698811en_US
dc.identifier.scopus2-s2.0-85132919672en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1080/00207454.2022.2089136
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7857
dc.identifier.wosWOS:000815816400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApigeninen_US
dc.subjectbrainen_US
dc.subjectmouseen_US
dc.subjectMPTPen_US
dc.subjectParkinson's diseaseen_US
dc.titleApigenin alleviates neuroinflammation in a mouse model of Parkinson's diseaseen_US
dc.typeArticleen_US

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