Antimicrobial activity of the extracts and physalin D from Physalis alkekengi and evaluation of antioxidant potential of physalin D

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dc.authoridKoroglu, Aysegul/0000-0002-8450-1376
dc.authoridHELVACI, SOMER/0000-0001-5142-4979
dc.contributor.authorHelvaci, S.
dc.contributor.authorKokdil, G.
dc.contributor.authorKawai, M.
dc.contributor.authorDuran, N.
dc.contributor.authorDuran, G.
dc.contributor.authorGuvenc, A.
dc.date.accessioned2024-09-18T19:54:32Z
dc.date.available2024-09-18T19:54:32Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPhysalis alkekengi L. (Solanaceae) is a popular plant in traditional European and Chinese folk medicine, and it has been reported to have many ethnopharmacological properties including antifungal, anti-cough, anti-inflammatory, analgesic, and febricide activities. Some active components from Physalis species have been investigated. However, no antimicrobial activity studies on extracts and physalins of P. alkekengi have been carried out. In this study, we attempted to identify the possible antimicrobial activities of the methanol extract from aerial parts of P. alkekengi and the dichloromethane extract from calyces of the plant. The extracts were tested against five Gram-positive and five Gram-negative bacteria and five Candida species by using disk diffusion and broth microdilution methods. The extracts were fractionated to isolate physalins using chromatographic techniques, and physalin D was isolated from the extracts. The structure of the compound was elucidated on the basis of H-1-NMR spectroscopic study, and confirmed by comparison with a reference sample and literature data. Results indicated that all the extracts and physalin D were characterized by antibacterial action, especially against Gram-positive bacteria, with MIC values between 32 and 128 mu g/mL. The methanol extract had moderate activity against fungi at MICs ranging from 128 to 512 mu g/mL, but the dichloromethane extract and physalin D had low activity against fungi at MICs ranging from 256 to 512 mu g/mL. Additionally, the antioxidant activity of physalin D was evaluated by qualitative DPPH (1,1-diphenyl-2-picrylhydrazyl) radical and TBA (thiobarbituric acid) assays. Physalin D showed low antioxidant activity with an IC50 value of >= 10 +/- 2.1.en_US
dc.description.sponsorshipUniversity of Mersin [BAP-SBE EMB (SH) 2003-2YL]en_US
dc.description.sponsorshipThe financial support of the research fund of the University of Mersin (project number: BAP-SBE EMB (SH) 2003-2YL) is gratefully acknowledged. The authors thank Assoc. Prof. Ayse Everest (Department of Biology, Faculty of Arts and Sciences, University of Mersin, Mersin, Turkey) for identification of the plant material. The authors are grateful to Prof. H. Yamamura, Graduate School of Engineering, Nagoya Institute of Technology, for 1H-NMR measurements.en_US
dc.identifier.doi10.3109/13880200903062606
dc.identifier.endpage150en_US
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.issue2en_US
dc.identifier.pmid20645830en_US
dc.identifier.scopus2-s2.0-76149143421en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage142en_US
dc.identifier.urihttps://doi.org/10.3109/13880200903062606
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7786
dc.identifier.volume48en_US
dc.identifier.wosWOS:000273871900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPharmaceutical Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntimicrobial activityen_US
dc.subjectantioxidant activityen_US
dc.subjectextractionen_US
dc.subjectisolationen_US
dc.subjectphysalin Den_US
dc.subjectPhysalis alkekengien_US
dc.titleAntimicrobial activity of the extracts and physalin D from Physalis alkekengi and evaluation of antioxidant potential of physalin Den_US
dc.typeArticleen_US

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