The ameliorative effects of Ginkgo biloba on apoptosis, LH-R expression and sperm morphology anomaly in testicular torsion and detorsion

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dc.contributor.authorGevrek, F.
dc.contributor.authorBicer, C.
dc.contributor.authorKara, M.
dc.contributor.authorErdemir, F.
dc.date.accessioned2024-09-18T20:25:24Z
dc.date.available2024-09-18T20:25:24Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractTorsion/detorsion (T/D) induces testicular damages in both germinal epithelial and interstitial tissues. Ginkgo biloba extract (GbE) exerts antioxidant and free radical scavenger. We investigated the effect of GbE on testicular tissues, Leydig and sperm cells in rats injured with T/D. Twenty-eight Wistar albino rats were randomly assigned into four groups (Control, GbE, Treatment: T/D+GbE, T/D). T/D performed to the rats in torsion, treatment received GbE (50mg/kg) 1hr before T/D, GbE group received only GbE (50mg/kg) and control was defined as sham group. After T/D, the testes along with epididymis were removed and processed. LH-R expression, apoptosis, sperm morphology and histopathological damage scores were determined for each group. Testicular T/D caused significant increases in apoptosis and sperm morphology anomaly, and a significant decrease in Johnsen's testicular biopsy scores, LH-R expression of Leydig cell and normal sperm cell count. GbE ameliorated testicular histopathology and caused significant increases in LH-R expression, normal sperm cell count in the treated and particularly GbE group. Consequently, GbE may prevent testicular injury and enhance Leydig and sperm cell activity following both T/D and normal situation owing to its antioxidant, anti-apoptotic, free radical scavenger and anti-inflammatory effects.en_US
dc.description.sponsorshipGaziosmanpasa University Scientific Research Foundation [2013-113]en_US
dc.description.sponsorshipGaziosmanpasa University Scientific Research Foundation, Grant/Award Number: 2013-113en_US
dc.identifier.doi10.1111/and.12969
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue4en_US
dc.identifier.pmid29411888en_US
dc.identifier.scopus2-s2.0-85041691194en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1111/and.12969
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10282
dc.identifier.volume50en_US
dc.identifier.wosWOS:000429536900028en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAndrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGinkgo biloba extracten_US
dc.subjectleydigen_US
dc.subjectspermen_US
dc.subjecttestisen_US
dc.subjecttorsionen_US
dc.titleThe ameliorative effects of Ginkgo biloba on apoptosis, LH-R expression and sperm morphology anomaly in testicular torsion and detorsionen_US
dc.typeArticleen_US

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