The effects of 4-thujanol on chromosome aberrations, sister chromatid exchanges and micronucleus in human peripheral blood lymphocytes

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dc.authoridIstifli, Erman Salih/0000-0003-2189-0703
dc.authoridBuyukleyla, Mehmet/0000-0002-4450-2710
dc.contributor.authorKocaman, Ayse Yavuz
dc.contributor.authorRencuzogullari, Eyyup
dc.contributor.authorTopaktas, Mehmet
dc.contributor.authorIstifli, Erman Salih
dc.contributor.authorBuyukleyla, Mehmet
dc.date.accessioned2024-09-18T19:47:58Z
dc.date.available2024-09-18T19:47:58Z
dc.date.issued2011
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstract4-Thujanol, a bicyclic monoterpene alcohol, is present in the essential oils of many medicinal and aromatic plants. It is commonly used as a fragrance and flavouring ingredient in a lot of different products. The potential genotoxic effects of 4-thujanol on human peripheral blood lymphocytes (PBLs) were investigated in vitro by the chromosome aberrations (CAs), sister chromatid exchanges (SCEs), and micronucleus (MN) tests. The cells were treated with 13, 26 and 52 mu g/mL 4-thujanol in the presence and absence of a metabolic activator (S9 mix). 4-Thujanol induced CA (P < 0.001) and MN formation (P < 0.05) at all concentrations (13, 26 and 52 mu g/mL) in the presence and absence of the S9 mix without a concentration-dependent manner. However, the treatment of peripheral lymphocytes with 4-thujanol did not produce a statistical difference in the frequency of SCEs when compared with control group. Furthermore, this monoterpene did not significantly decrease the mitotic index (MI), proliferation index (PI), and nuclear division index (NDI). In conclusion, 4-thujanol had a significant clastogenic effect at the tested concentrations (13, 26 and 52 mu g/mL) for human PBLs. In addition, no cytotoxic and/or cytostatic effects were observed regardless of the concentrations used. This work presents the first report on genotoxic properties of 4-thujanol.en_US
dc.description.sponsorshipScientific and Technical Research Council of Turkey, Ankara (TUBITAK) [109T546]en_US
dc.description.sponsorshipThis investigation was supported by a grant from The Scientific and Technical Research Council of Turkey, Ankara (TUBITAK, Project No. 109T546).en_US
dc.identifier.doi10.1007/s10616-011-9372-7
dc.identifier.endpage502en_US
dc.identifier.issn0920-9069
dc.identifier.issn1573-0778
dc.identifier.issue5en_US
dc.identifier.pmid21735266en_US
dc.identifier.scopus2-s2.0-84655161990en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage493en_US
dc.identifier.urihttps://doi.org/10.1007/s10616-011-9372-7
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7255
dc.identifier.volume63en_US
dc.identifier.wosWOS:000297835800006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofCytotechnologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject4-Thujanolen_US
dc.subjectHuman peripheral blood lymphocytesen_US
dc.subjectGenotoxicityen_US
dc.subjectChromosome aberrationsen_US
dc.subjectSister chromatid exchangesen_US
dc.subjectMicronucleusen_US
dc.titleThe effects of 4-thujanol on chromosome aberrations, sister chromatid exchanges and micronucleus in human peripheral blood lymphocytesen_US
dc.typeArticleen_US

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