Carvacrol showed a curative effect on reproductive toxicity caused by Bisphenol AF via antioxidant, anti-inflammatory and anti-apoptotic properties

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dc.authoridKANAT, Ozgur/0000-0002-9747-5496
dc.contributor.authorUyar, Ahmet
dc.contributor.authorCellat, Mustafa
dc.contributor.authorKanat, Ozgur
dc.contributor.authorEtyemez, Muhammed
dc.contributor.authorKutlu, Tuncer
dc.contributor.authorDeveci, Mehmet Yilmaz Zeki
dc.contributor.authorYavas, Ilker
dc.date.accessioned2024-09-18T20:08:04Z
dc.date.available2024-09-18T20:08:04Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBisphenol AF (BPAF) is an endocrine disruptor, and human exposure to these chemicals is growing in industrialized nations. BPAF has been demonstrated in studies to have toxic effects on reproductive health. This study examined the effects of oral exposure to BPAF on the reproductive system and the protective effects of carvacrol in rats. From 32 Wistar albino rats, four separate groups were set up for this purpose. Carvacrol 75 mg/kg and BPAF 200 mg/kg were administered by oral gavage method. Rat sperm parameters and serum testosterone levels were measured after 28 days of administration. The study looked at the MDA in the testis tissues, as well as CAT, GPx, and GSH as antioxidants parameters, NF-& kappa;B and TNF-& alpha; as inflammatory markers, caspase-3 and Bcl-2 as apoptosis parameters, and PCNA as cell proliferation markers. In addition, testis tissues underwent histological evaluation. As a result, in rats exposed to only BPAF, sperm counts declined, testosterone levels reduced, oxidative stress, inflammation, and apoptosis increased, and cell proliferation decreased. Furthermore, severe disruptions in tissue architecture and decreased spermatogenesis were reported. In contrast, sperm parameters improved, testosterone levels increased, oxidative stress and inflammation decreased, and apoptosis was prevented in the carvacrol-treated group compared to the BPAF-only group. It was also found that spermatogenesis was maintained, and structural abnormalities in testicular tissue were mostly avoided with an increase in PCNA expression. According to the findings, despite BPAF-induced testicular and reproductive toxicity, carvacrol had therapeutic potential due to its anti-inflammatory, antioxidant, cell proliferation-increasing, and anti-apoptotic activities.en_US
dc.identifier.doi10.1016/j.reprotox.2023.108456
dc.identifier.issn0890-6238
dc.identifier.issn1873-1708
dc.identifier.pmid37586593en_US
dc.identifier.scopus2-s2.0-85167995925en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.reprotox.2023.108456
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8594
dc.identifier.volume121en_US
dc.identifier.wosWOS:001065518200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofReproductive Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarvacrolen_US
dc.subjectBisphenol AFen_US
dc.subjectInfertilityen_US
dc.subjectAntioxidanten_US
dc.subjectInflammationen_US
dc.subjectApoptosisen_US
dc.titleCarvacrol showed a curative effect on reproductive toxicity caused by Bisphenol AF via antioxidant, anti-inflammatory and anti-apoptotic propertiesen_US
dc.typeArticleen_US

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