Effects of Propolis on Serum Biochemical Parameters in Azaserine Treated Rats

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dc.authorscopusid14044369000
dc.authorscopusid58859719000
dc.contributor.authorYıldız, Hasan
dc.contributor.authorMiçooğulları, Ümit
dc.date.accessioned2024-09-19T15:43:42Z
dc.date.available2024-09-19T15:43:42Z
dc.date.issued2022
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractAzaserine (o-diazoacetyl-L-serine) is an antimetabolite obtained from streptomycetes cultures and is used experimentally to produce atypical acinar cell focus (AACF) in rat exocrine pancreas. Propolis is a resinous hive product with antioxidant, anticarcinogenic, antimicrobial and anti-inflammatory effects that bees collect from the plants around them. In this study, we aimed performed to investigate the effect of ethanol extract of propolis (EEP) on serum biochemical changes in azaserin induced pancreatic cancer in Wistar rats. For this purpose, male Wistar albino rats were randomly divided into 4 groups, 10 in each group. AzCt and AzProp group 2-week-old male rats were given azaserine (30 mg/kg bw) intraperitoneally (ip). Propolis (EEP) (oral 80 mg/lt) was added to the drinking water of Prop and AzProp group rats. For the first time in this study, the effects of propolis on rats with neoplastic structures formed by azaserine were investigated in terms of biochemical parameters (AST, ALP, ALT, BILD, BILT, CHOL, LDH, TRIG, UREA, TAS, TOS and OSI). According to this; AzProp group values were compared to AzCt group, respectively, AST, UREA, TOS and OSI, there is a statistically significant difference in terms of values. As a result, it was seen that the oxidative stress caused by azaserine-induced neoplastic structures decreased with the use of propolis and that propolis had a positive effect on the measured biochemical parameters. © 2022, Natural and Engineering Science. All rights reserved.en_US
dc.description.sponsorshipHMKU-BAP; Hatay Mustafa Kemal Universityen_US
dc.identifier.doi10.28978/nesciences.1142700
dc.identifier.endpage96en_US
dc.identifier.issn2458-8989
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85183890474en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.28978/nesciences.1142700
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14511
dc.identifier.volume7en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherNatural and Engineering Scienceen_US
dc.relation.ispartofNatural and Engineering Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAzaserineen_US
dc.subjectoxidative stressen_US
dc.subjectpropolisen_US
dc.subjectserumen_US
dc.titleEffects of Propolis on Serum Biochemical Parameters in Azaserine Treated Ratsen_US
dc.typeArticleen_US

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