Caffeic acid phenethyl ester protects rabbit brains against permanent focal ischemia by antioxidant action: A biochemical and planimetric study

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dc.authoridBal, Ramazan/0000-0003-3829-8669
dc.authoridDUMAN, Taskin/0000-0002-6552-4193
dc.contributor.authorAltug, Muhammed Enes
dc.contributor.authorSerarslan, Yurdal
dc.contributor.authorBal, Ramazan
dc.contributor.authorKontas, Tuenay
dc.contributor.authorEkici, Fatih
dc.contributor.authorMelek, Ismet M.
dc.contributor.authorAslan, Hueseyin
dc.date.accessioned2024-09-18T20:06:20Z
dc.date.available2024-09-18T20:06:20Z
dc.date.issued2008
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThe present study was conducted to investigate whether caffeic acid phenethyl ester (CAPE), an active component of propolis extract, has a protective effect on brain injury after focal permanent cerebral ischemia, and to determine the possible antioxidant mechanisms. Cerebral infarction in adult male New Zealand rabbits was induced by microsurgical procedures producing right focal permanent middle cerebral artery occlusion (pMCAO). CAPE was administered to the treatment group after pMCAO at a dose of 10 mu mol kg(-1) once a day intraperitoneally for 7 days. Neurological deficits were evaluated, using a modified six-point scale. Spectrophotometric assay was used to determine the contents of malondialdehyde (MDA), glutathione (GSH), catalase (CAT), nitric oxide (NO) and xanthine oxidase (XO). In the ipsilateral hemisphere, the infarct volume of the brain was assessed in brain slices stained with heamatoxylen and eosin. The results showed that treatment with CAPE significantly reduced the percentage of infarction in the ipsilateral hemisphere compared with the ischemia group. CAPE treatment significantly attenuated the elevation of plasma MDA, CAT and XO content (p < 0.05), whereas it significantly increased the levels of plasma GSH and NO (p < 0.05). Therefore, subacute CAPE administration plays a protective role in focal pMCAO due to attenuation of lipid peroxidation and its antioxidant activity. All of these findings suggest that CAPE provides neuroprotection against cerebral ischemia injury through its antioxidant action. (C) 2008 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.brainres.2008.01.053
dc.identifier.endpage142en_US
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pmid18308295en_US
dc.identifier.scopus2-s2.0-40849101557en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage135en_US
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2008.01.053
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8470
dc.identifier.volume1201en_US
dc.identifier.wosWOS:000255065600017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBrain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcaffeic acid phenethyl esteren_US
dc.subjectantioxidant activityen_US
dc.subjectfocal permanent cerebral ischemiaen_US
dc.subjectneuroprotectionen_US
dc.subjectrabbiten_US
dc.titleCaffeic acid phenethyl ester protects rabbit brains against permanent focal ischemia by antioxidant action: A biochemical and planimetric studyen_US
dc.typeArticleen_US

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