Effect of Thiocolchicoside on Midline Closure in Early Chicken Embryos

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dc.contributor.authorEken, Recep
dc.contributor.authorKesilmez, Emrullah Cem
dc.contributor.authorSecinti, Kutsal Devrim
dc.contributor.authorAkkaya, Zeynep Kahyaoglu
dc.contributor.authorSecinti, Ilke Evrim
dc.contributor.authorTurkoglu, Hasan
dc.contributor.authorYuksel, Zafer
dc.date.accessioned2024-09-18T20:59:24Z
dc.date.available2024-09-18T20:59:24Z
dc.date.issued2024
dc.departmentHatay Mustafa Kemal Ãœniversitesien_US
dc.description.abstractBACKGROUND/AIMS: Thiocolchicoside (TCC) is a semi-synthetic derivative of colchicine analog, a muscle relaxant with analgesic and antiinflammatory activity. Studies have shown that colchicine inhibits microtubule polymerization and stops mitotic activity, and that TCC is a competitive antagonist of g-aminobutyric acid A and glycine receptors. It is known that the use of TCC during pregnancy may have teratogenic effects. We aimed to examine the effects of drugs with TCC as their active ingredient, which are frequently used in clinical practice, on the development of chicken embryos and midline closure. MATERIALS AND METHODS: A total of 80 eggs were incubated in an incubator for 24 hours. At the 24th hour of incubation, the eggs were divided into 4 groups. Increasing doses of TCC (8 mcg, 16 mcg, 32 mcg) in 0.1 cc solutions were applied to these groups and half of the control group was administered physiological saline, corresponding to the air sac. All eggs were then closed with sterile tapes and replaced in the incubator. On the 10th day of incubation, the eggs were hatched and the embryos were evaluated morphologically and histopathologically. RESULTS: TCC caused a high rate of early embryo death (EED) in all groups in which it was applied. Although midline closure defects were detected in some of the developing embryos, it was not statistically significant. CONCLUSION: EED and midline closure defects were observed in some developing embryos in the TCC applied groups. It will be possible to understand the mechanism of embryonic damage, to reveal teratogenic effects and to minimize the formation of congenital defects with more comprehensive studies.en_US
dc.description.sponsorshipFinancial Disclosure: The authors declared that this study had received no financial support.en_US
dc.identifier.doi10.4274/cjms.2024.2023-45
dc.identifier.endpage184en_US
dc.identifier.issn2149-7893
dc.identifier.issn2536-507X
dc.identifier.issue3en_US
dc.identifier.startpage180en_US
dc.identifier.urihttps://doi.org/10.4274/cjms.2024.2023-45
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12553
dc.identifier.volume9en_US
dc.identifier.wosWOS:001274070500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofCyprus Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThiocolchicosideen_US
dc.subjectneural tube defecten_US
dc.subjectchicken embryoen_US
dc.titleEffect of Thiocolchicoside on Midline Closure in Early Chicken Embryosen_US
dc.typeArticleen_US

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