Effects of Intravenous Small Dose Ketamine and Midazolam on Postoperative Pain Following Knee Arthroscopy

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dc.contributor.authorAkkurt, Buket Cagla Ozbakis
dc.contributor.authorInanoglu, Kerem
dc.contributor.authorKalacı, Aydıner
dc.contributor.authorTurhanoglu, Selim
dc.contributor.authorAsfuroglu, Zeynel
dc.contributor.authorTumkaya, Feray
dc.date.accessioned2024-09-18T20:28:15Z
dc.date.available2024-09-18T20:28:15Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBackground: The aim of this randomized, double blind, controlled study was to assess the effect of intravenous coadministration of small dose midazolam with ketamine on postoperative pain and spinal block level. Methods: Sixty patients undergoing arthroscopic knee surgery under spinal anesthesia were randomized into three groups: Group I (saline control); group II (ketamine 0.15 mg/kg i.v.); and group III (ketamine 0.15 mg/kg + midazolam 0.01 mg/kg i.v.). Sedation scores, visual analogue scores, time to first postoperative analgesic, total meperidine consumption, patient satisfaction, sensory and motor block levels, and two segments regression times were assessed. Results: Sedation scores were significantly lower in group I when compared with groups II and III at 1, 3, 5, and 10 minutes after administration of the spinal anesthetic (P = 0.001). Sensory block was significantly higher in group III (P = 0.001) in comparison with group II. Two segment regression time was significantly longer in group II than group I, whereas no difference was found between groups II and III. Total meperidine consumption was significantly higher in group I (P = 0,001). Patient satisfaction was significantly higher in group III compared with group I (P = 0.001), but no difference was found between groups II and III (P = 0.3). Conclusion: Ketamine improved the postoperative pain patient satisfaction, increased the maximal sensory level, and was associated with lower sedation scores in the first 15 minutes after administration. Group I was also associated with decreased total meperidine consumption and delayed the time to first recue analgesic administration. Coadministration of ketamine and midazolam did not provide any further benefit over ketamine alone.en_US
dc.identifier.doi10.1111/j.1533-2500.2009.00278.x
dc.identifier.endpage295en_US
dc.identifier.issn1530-7085
dc.identifier.issn1533-2500
dc.identifier.issue4en_US
dc.identifier.pmid19490462en_US
dc.identifier.scopus2-s2.0-67650685539en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://doi.org/10.1111/j.1533-2500.2009.00278.x
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10812
dc.identifier.volume9en_US
dc.identifier.wosWOS:000208107800007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPain Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectketamineen_US
dc.subjectpostoperative painen_US
dc.subjectknee arthroscopyen_US
dc.subjectrandomized controlled trialen_US
dc.subjectspinal anesthesiaen_US
dc.subjectpreemptive analgesiaen_US
dc.titleEffects of Intravenous Small Dose Ketamine and Midazolam on Postoperative Pain Following Knee Arthroscopyen_US
dc.typeArticleen_US

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