Amitriptyline and tianeptine poisoning treated by naloxone

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dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.contributor.authorAri, Mustafa
dc.contributor.authorOktar, Suleyman
dc.contributor.authorDuru, Mehmet
dc.date.accessioned2024-09-18T19:54:16Z
dc.date.available2024-09-18T19:54:16Z
dc.date.issued2010
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Severe amitriptyline toxicity may cause cardiac dysrhythmias, severe hypotension, convulsions and CNS depression, including coma. Management with gastric lavage, activated charcoal, alkalinization and supportive care with mechanical ventilation, antiarrhythmics and anticonvulsants, if required, is the general approach. Case report: A 33-year-old woman who has taken overdose antidepressants (amitriptyline and tianeptine) was admitted to the emergency service. She was intubated because she had pure respiratory arrest. Besides hypotension (80/60 mmHg), she was unresponsive to verbal and painful stimuli and her Glasgow coma score was 6. Hemogram and serum biochemical parameters and electrocardiography were within normal limits. The patient was examined for substance dependence and no trace of the injector was found in the body. Patient underwent a coma cocktail (naloxone 2 mg/kg, 5% dextrose 25 g/body and tiamin 100 g/body). Activated charcoal and intravenous alkalinization by NaHCO3 were initiated. Spontaneous respiration started again 20 min after being given the coma cocktail. She became responsive to verbal stimuli first hour after the coma cocktail, and her Glasgow coma score improved to 13. She had spent 2 days in the service and was discharged by the second day of admission, without any complications. Discussion: Herein, we report successful treatment in a case of severe amitriptyline and tianeptine poisoning by naloxone in addition to the above supportive care. Naloxone treatment may have a beneficial role in lethal doses of amitriptyline ingestion because amitriptyline may affect opioid receptors.en_US
dc.identifier.doi10.1177/0960327110372403
dc.identifier.endpage795en_US
dc.identifier.issn0960-3271
dc.identifier.issn1477-0903
dc.identifier.issue9en_US
dc.identifier.pmid20498036en_US
dc.identifier.startpage793en_US
dc.identifier.urihttps://doi.org/10.1177/0960327110372403
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7616
dc.identifier.volume29en_US
dc.identifier.wosWOS:000282039100011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofHuman & Experimental Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectamitriptylineen_US
dc.subjecttianeptineen_US
dc.subjectnaloxoneen_US
dc.subjectacute poisoningen_US
dc.titleAmitriptyline and tianeptine poisoning treated by naloxoneen_US
dc.typeArticleen_US

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