The effect of subthalamic nucleus - Deep brain stimulation and different stimulation frequencies on cerebral hemodynamics in Parkinson's disease: A transcranial doppler study

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dc.authoridYildizgoren, Mustafa Turgut/0000-0002-9697-6184
dc.authoridYILMAZ, Atilla/0000-0002-1081-3545
dc.authoridOral, Sukru/0000-0003-4328-0690
dc.contributor.authorKoban, Orkun
dc.contributor.authorYildizgoren, Mustafa Turgut
dc.contributor.authorAras, Mustafa
dc.contributor.authorOral, Sukru
dc.contributor.authorUyanik, Sadik Ahmet
dc.contributor.authorSerarslan, Yurdal
dc.contributor.authorOkuyucu, Esra Emine
dc.date.accessioned2024-09-18T20:15:02Z
dc.date.available2024-09-18T20:15:02Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: To investigate the effect of deep brain stimulation of the subthalamic nucleus (STN-DBS) and to compare low-frequency versus high-frequency STN-DBS on hemodynamic parameters of the middle cerebral artery between patients with advanced Parkinson's disease and age-sex matched healthy controls. Patients and Methods: Eighteen patients with advanced Parkinson's disease (PD) with bilateral STN-DBS and 18 control subjects underwent Transcranial Doppler Ultrasound (TCDU) were included in the study. The hemodynamic parameters including blood flow velocity (FV), pulsatility index (PI) and, resistance index (RI) of the right middle cerebral artery (MCA) were measured and compared during the phases using TCDU. The first DBS-off, the second low-frequency DBS of 60 Hz, and the third high-frequency DBS of 130 Hz were compared. Results: PD patients had significantly higher MCA-PI values compared with controls (0.99 +/- 0.27 vs. 0.82 +/- 0.14) (p = 0.031). Also, the MCA-PI values were higher in the low-frequency DBS (0.94 +/- 0.14) and high-frequency DBS (0.93 +/- 0.16) than in the controls (0.82 +/- 0.14) (p = 0.022 and p = 0.041, respectively). There were no significant differences of FV and RI values among the DBS-on, DBS-off and, controls. The RI values were higher in the PD patients than in the controls, although these were not statistically significant. Also, PI values of the MCA decrease in different frequencies (60 Hz or 130 Hz). Conclusion: The results of this study showed that MCA-PI values are higher in advanced PD compared with controls. These indices indicate that MCA resistances and impedances are increased in advanced PD. Low- or high-frequency DBS treatment have beneficial effect to reduce high PI in advanced PD patients.en_US
dc.identifier.doi10.1016/j.clineuro.2020.105778
dc.identifier.issn0303-8467
dc.identifier.issn1872-6968
dc.identifier.pmid32200216en_US
dc.identifier.scopus2-s2.0-85081644158en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.clineuro.2020.105778
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9403
dc.identifier.volume193en_US
dc.identifier.wosWOS:000534371300023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinical Neurology and Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDeep brain stimulationen_US
dc.subjectBlood flow velocityen_US
dc.subjectPulsatility indexen_US
dc.subjectResistance indexen_US
dc.subjectTranscranial doppler ultrasounden_US
dc.titleThe effect of subthalamic nucleus - Deep brain stimulation and different stimulation frequencies on cerebral hemodynamics in Parkinson's disease: A transcranial doppler studyen_US
dc.typeArticleen_US

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