Effect of oral misoprostol, alone or in combination with aglepristone, on mid-term pregnancy termination in cats

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dc.authoriday, serhan serhat/0000-0003-2116-5149
dc.authoridFINDIK, Murat/0000-0003-1408-2548
dc.contributor.authorAy, Serhan Serhat
dc.contributor.authorAslan, Selim
dc.contributor.authorOnyay, Firdevs
dc.contributor.authorKaya, Duygu
dc.contributor.authorKoldas, Ece
dc.contributor.authorArslan, Serhat
dc.contributor.authorFindik, Murat
dc.date.accessioned2024-09-18T20:54:28Z
dc.date.available2024-09-18T20:54:28Z
dc.date.issued2019
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives This study aimed to determine the efficacy and safety of oral misoprostol (MIS) administration in the induction of mid-term pregnancy termination in cats. Methods Twenty-eight cats that were pregnant for 30-40 days were allocated to four groups. The aglepristone (AGL) group (n = 7) received 10 mg/kg SC aglepristone q24h for two consecutive days. In the AGL+MIS group (n = 7), AGL (as administered in the AGL group) and MIS (200 mu g/cat PO q12h until the start of abortion) were administered. The MIS200 (n = 7) and MIS400 groups (n = 7) received MIS (200 or 400 mu g/cat misoprostol, respectively) alone PO q12h until the start of abortion. Blood samples were collected at the start of treatment (d0), 4 days after the start of treatment (d4) and on the day of complete abortion/end of administration (dA/d7). Results The efficacy of the treatment was 71.4% in the AGL group, 100% in the AGL+MIS group, 0% in MIS200 group and 57.4% in MIS400 group (P = 0.004). No significance was found in relation to the interval from treatment to the start/end of abortion and the duration of abortion in all groups. The most observed side effect was vomiting in both groups administered MIS, particularly in the MIS400 group (56.7%). Progesterone (P4) concentrations were reduced during the abortion, but not to basal levels, in all groups. P4 concentrations were significantly lower at dA/d7 in the MIS400 group compared with the AGL and AGL+MIS groups (P = 0.002). Conclusions and relevance The results obtained from this study showed that low doses of MIS do not induce abortions in cats but increase the effect of AGL. Although higher doses could terminate pregnancies, this also causes intense unwanted side effects. Therefore, the use of MIS alone as an abortifacient in cats is not recommended. For mid-term pregnancy termination in cats, the combination of misoprostol and aglepristone provides a more effective abortifacient than using either of them alone.en_US
dc.identifier.doi10.1177/1098612X18797139
dc.identifier.endpage722en_US
dc.identifier.issn1098-612X
dc.identifier.issn1532-2750
dc.identifier.issue8en_US
dc.identifier.pmid30230409en_US
dc.identifier.scopus2-s2.0-85060098792en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage714en_US
dc.identifier.urihttps://doi.org/10.1177/1098612X18797139
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11820
dc.identifier.volume21en_US
dc.identifier.wosWOS:000477648200008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of Feline Medicine and Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPregnancy terminationen_US
dc.subjectPGE1en_US
dc.subjectaglepristoneen_US
dc.subjectmid-term pregnancyen_US
dc.subjectmisoprostolen_US
dc.titleEffect of oral misoprostol, alone or in combination with aglepristone, on mid-term pregnancy termination in catsen_US
dc.typeArticleen_US

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