Single-dose fosfomycin could prevent infectious complications after retrograde intrarenal surgery: A prospective study
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Masson, Corp Off
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background. - In this study, we aimed to show the protective effect of a single-dose Fosfomycin from infective complications against the standard usage of cephalosporine before retrograde intrarenal surgery. Material. - A total of 186 patients who underwent retrograde intrarenal surgery between 2020 and 2021, included the study. Patients were divided into two groups: group 1(n = 49), patients who received an oral dose of 3 g Fosfomycin tromethamine powder administered 4-6 h before the operation; and group 2 (n = 137): patients who received Cephalosporin 30 min before surgery and an additional dose 6 h after surgery.Results. - The median age and stone size were significantly higher in the cephalosporin group (P = 0.006 and P = 0.008, respectively). There was no statistically significant difference between the groups in terms of postoperative fever and postoperative UTI (P = 0.408 and P = 0.438). Additionally, no patient developed sepsis. and no adverse event was seen in either group. Preoperative urinary tract infection (UTI) and previous Extracorporeal Shock Wave lithotripsy (ESWL) were independent risk factors and increased postoperative infectious complications (O.R. 2.929 95% C.I. 0.723, P < 0.001, and O.R. 2.860 95% C.I. 0.985, P = 0.004, respectively). Conclusion. - Infectious is still one of the important complications after RIRS, and preoperative UTI is an independent risk factors for infections. Fosfomycin monotherapy could be sufficient and is also effective in patients with preoperative culture positive. (c) 2022 Elsevier Masson SAS. All rights reserved.
Açıklama
Anahtar Kelimeler
Urolithiasis, Prophylaxis, Antibiotherapy, Fosfomycin, Infectious complications, Retrograde intrarenal surgery
Kaynak
Progres En Urologie
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
33
Sayı
3
