Investigation of serum bisphenol A, vitamin D, and parathyroid hormone levels in patients with obstructive sleep apnea syndrome

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dc.authoridSungur, Sana/0000-0001-7370-8972
dc.authoridOktar, Suleyman/0000-0003-0151-5981
dc.authoridUstun, Ihsan/0000-0002-5848-1586
dc.authoridUlutas, Kemal Turker/0000-0003-2852-0449
dc.contributor.authorErden, Ersin Sukru
dc.contributor.authorGenc, Sebahat
dc.contributor.authorMotor, Sedat
dc.contributor.authorUstun, Ihsan
dc.contributor.authorUlutas, Kemal Turker
dc.contributor.authorBilgic, Hatice Kayim
dc.contributor.authorOktar, Suleyman
dc.date.accessioned2024-09-18T20:04:32Z
dc.date.available2024-09-18T20:04:32Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObstructive sleep apnea syndrome (OSAS) is a common health problem, and associated with obesity, metabolic syndrome (MetS), and diabetes. Growing evidence shows that 25-hydroxyvitamin-D-3 (25-OH-D) insufficiency and high parathyroid hormone (PTH) levels may be correlated to glucose intolerance, MetS, obesity, and cardiovascular abnormalities similar to OSAS. Bisphenol A (BPA) is an endocrine disruptor agent which exerts a wide variety of metabolic effects. It has estrogenic activity and its exposure may contribute to weight gain, obesity, impaired glucose metabolism, and the development of diabetes, also similar to OSAS. The aim of this study is to investigate the relationships between OSAS and serum BPA, 25-OH-D, and PTH levels. This study enrolled 128 subjects, with all of the OSAS patients having been diagnosed by polysomnography. The 128 subjects were divided into three groups: a control (n = 43), a moderate OSAS (n = 23) (AHI = 15-30), and a severe OSAS groups (n = 62) (AHI > 30). The serum BPA, 25-OH-D, and PTH levels for each subject were analyzed. 25-OH-D was lower in both OSAS groups, and PTH was higher in the OSAS groups than in the control subjects. The BPA levels were higher in the severe OSAS group than the moderate OSAS and control. There was a positive correlation between the BPA and body mass index, and a negative correlation between the 25-OH-D and BPA levels in all of the individuals. OSAS is related to high BPA and PTH levels, and low vitamin D levels. There is a positive association between BPA levels and OSAS, and the severity of OSAS. These results suggest that the BPA levels may have a role in the pathogenesis of OSAS.en_US
dc.identifier.doi10.1007/s12020-013-0022-z
dc.identifier.endpage318en_US
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue2en_US
dc.identifier.pmid23904340en_US
dc.identifier.scopus2-s2.0-84896696025en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage311en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-013-0022-z
dc.identifier.urihttps://hdl.handle.net/20.500.12483/8234
dc.identifier.volume45en_US
dc.identifier.wosWOS:000331639000021en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEndocrineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBisphenol Aen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.subjectVitamin Den_US
dc.subjectParathyroid hormoneen_US
dc.titleInvestigation of serum bisphenol A, vitamin D, and parathyroid hormone levels in patients with obstructive sleep apnea syndromeen_US
dc.typeArticleen_US

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