The Cytokines-Directed Roles of Spirulina for Radioprotection of Lacrimal Gland

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dc.authoridYazihan, Nuray/0000-0003-1237-8468
dc.authoridKoca, Gokhan/0000-0003-2842-9223
dc.authoridAKBULUT, Aylin/0000-0003-4665-7895
dc.contributor.authorAtilgan, H., I
dc.contributor.authorAkbulut, A.
dc.contributor.authorYazihan, N.
dc.contributor.authorYumusak, N.
dc.contributor.authorSingar, E.
dc.contributor.authorKoca, G.
dc.contributor.authorKorkmaz, M.
dc.date.accessioned2024-09-18T20:55:37Z
dc.date.available2024-09-18T20:55:37Z
dc.date.issued2023
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractPurpose To evaluate the radioprotective effect of spirulina (SP) on the lacrimal glands after RAI treatment. Methods A total of 30 rats were separated into control, RAI and SP group. The radioprotective effect of SP on lacrimal glands was evaluated with histopathological and cytopathological analysis. Lacrimal glands were analyzed for tumor necrosis factor alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10, nuclear factor-kappa B (NF-kappa B), total oxidant status (TOS) and total antioxidant capacity (TAC) levels. Results RAI increased TNF-alpha (p = .001), IL-6 (p = .018), and NF-kappa B levels (p < .0005). Following the administration of SP, TNF-alpha (p < .0005), IL-4 (p = .026), and IL-6 (p = .006) levels decreased. RAI decreased the TAC levels (p = .001), and co-administration of SP increased the TAC level, but was not statistically significant. SP decreased the TOS level after RAI (p = .022) . Conclusions SP protects lacrimal glands from RAI-induced damage.en_US
dc.identifier.doi10.1080/09273948.2022.2026409
dc.identifier.endpage276en_US
dc.identifier.issn0927-3948
dc.identifier.issn1744-5078
dc.identifier.issue2en_US
dc.identifier.pmid35050831en_US
dc.identifier.scopus2-s2.0-85123401556en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage271en_US
dc.identifier.urihttps://doi.org/10.1080/09273948.2022.2026409
dc.identifier.urihttps://hdl.handle.net/20.500.12483/11964
dc.identifier.volume31en_US
dc.identifier.wosWOS:000744926600001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofOcular Immunology and Inflammationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRadioiodine (RAI)en_US
dc.subjectspirulinaen_US
dc.subjectradiationen_US
dc.subjectradioprotectionen_US
dc.subjectcytokinesen_US
dc.titleThe Cytokines-Directed Roles of Spirulina for Radioprotection of Lacrimal Glanden_US
dc.typeArticleen_US

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