Effects of sulforophane and curcumin on oxidative stress created by acute malathion toxicity in rats

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dc.authoridAytekin, Ismail/0000-0001-6794-5453
dc.contributor.authorAlp, H.
dc.contributor.authorAytekin, I.
dc.contributor.authorHatipoglu, N. K.
dc.contributor.authorAlp, A.
dc.contributor.authorOgun, M.
dc.date.accessioned2024-09-18T20:13:39Z
dc.date.available2024-09-18T20:13:39Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractBACKGROUND AND OBJECTIVES, Organophosphate insecticides (OPIs) are widely used in agriculture and horticulture for controlling insects in crops, ornamentals, lawns, fruits, and vegetables. But, there have not yet any study about effects of sulforophane (SFN) and curcumin (CUR) on the oxidative stress created by acute toxic effects of malathion (MAL) as an OPI often causing human and animal poisoning. AIM, The aim of this study was to investigate the effects of SFN and CUR on the oxidative stress created in the lung, liver, and kidney tissues of rats by acute MAL toxicity. MATERIALS AND METHODS, Thirty-six mature Sprague Dawley rats weighing 200-250 g were used. The rats were randomly divided into six groups: unmedicated control, SFN, CUR, MAL control, MAL + SFN, and MAL + CUR. Tissue samples were analyzed for glutathione (GSH), malondialdehyde (MDA), and nitric oxide (NO) levels in the lung, liver, and kidney tissues. Biochemical parameters were measured colorimetrically by using a spectrophotometer. RESULTS, No statistically significantly difference was found when comparing the unmedicated control, SFN, and CUR groups. MAL significantly increased MDA levels in the liver and kidney tissues, but SFN and CUR these levels. MAL did significantly reduce the GSH levels, but SFN and CUR increased these levels by blocking the MAL effect in the liver tissues. Also, MAL significantly increased the NO levels, depending on the severity of the tissue damage, and SFN and CUR attenuated to NO levels and remained under the effect of MAL. CONCLUSIONS, SFN and CUR, which showed similar effects, could be used to protect against the oxidative stress caused by acute malathion intoxication.en_US
dc.identifier.endpage148en_US
dc.identifier.issn1128-3602
dc.identifier.pmid22957429en_US
dc.identifier.scopus2-s2.0-84864209775en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage144en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9310
dc.identifier.volume16en_US
dc.identifier.wosWOS:000307130900018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCurcuminen_US
dc.subjectMalathionen_US
dc.subjectOrganophosphateen_US
dc.subjectOxidative Stressen_US
dc.subjectSulforophaneen_US
dc.titleEffects of sulforophane and curcumin on oxidative stress created by acute malathion toxicity in ratsen_US
dc.typeArticleen_US

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