Protective effect of Celtis tournefortii against copper-induced toxicity in rat liver

Basit Öğe Kaydı
dc.contributor.authorTemiz, Mehmet Ali
dc.contributor.authorTemur, Atilla
dc.contributor.authorAkgeyik, Yusuf
dc.contributor.authorUyar, Ahmet
dc.date.accessioned2024-09-18T19:54:37Z
dc.date.available2024-09-18T19:54:37Z
dc.date.issued2021
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThis study aimed to investigate the antioxidant and hepatoprotective effects of Celtis tournefortii fruit extract (Ct) against copper-induced liver damage in rats. Thirty-two Wistar Albino rats were divided into four equal groups (n = 8): Control, Copper (Cu), Copper + C. tournefortii (Cu+Ct), and C. tournefortii (Ct). Superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities, glutathione (GSH) concentration, malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS) were analysed in the liver tissues. Liver histopathology was also evaluated. Alanine aminotransferase and lactate dehydrogenase significantly decreased in the Cu+Ct group compared with the Cu group. Oxidative stress parameters MDA and TOS significantly increased with copper administration, whereas they decreased with C. tournefortii co-treatment compared to Cu group. GSH concentration and TAS showed significant decreases with copper administration. Celtis tournefortii co-supplementation with copper significantly enhanced antioxidant parameters such as TAS, SOD, and GPx. Celtis tournefortii remarkably attenuated degenerative and necrotic changes caused by the oral exposure of copper in the liver tissue of rats. Celtis tournefortii may provide amelioration of the antioxidant status and moderation of severity of liver damage against copper toxicity. The therapeutic use of C. tournefortii may exhibit protective effects in liver injury treatment.en_US
dc.description.sponsorshipVan Yuzuncu Yil University Scientific Research Projects Foundation [FYL-2016-5479]en_US
dc.description.sponsorshipThis research was supported by the Van Yuzuncu Yil University Scientific Research Projects Foundation (grant number FYL-2016-5479).en_US
dc.identifier.doi10.2754/avb202190010091
dc.identifier.endpage98en_US
dc.identifier.issn0001-7213
dc.identifier.issn1801-7576
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85104707334en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage91en_US
dc.identifier.urihttps://doi.org/10.2754/avb202190010091
dc.identifier.urihttps://hdl.handle.net/20.500.12483/7829
dc.identifier.volume90en_US
dc.identifier.wosWOS:000654628800012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVeterinarni A Farmaceuticka Univerzita Brnoen_US
dc.relation.ispartofActa Veterinaria Brnoen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjecthepatoprotectiveen_US
dc.subjectoriental hackberryen_US
dc.subjectphytochemicalsen_US
dc.subjectTASen_US
dc.subjectTOSen_US
dc.titleProtective effect of Celtis tournefortii against copper-induced toxicity in rat liveren_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
7829.pdf
Boyut:
2.65 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu