Effects of vitamin D3 and calcium on fracture healing in rats

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dc.authorscopusid15070071900
dc.authorscopusid8855265500
dc.authorscopusid8855265900
dc.authorscopusid36876295100
dc.authorscopusid8855265700
dc.authorscopusid8855265800
dc.contributor.authorAslan, Bahadir
dc.contributor.authorKalaci, Aydmer
dc.contributor.authorBozlar, Murat
dc.contributor.authorAtik, Esin
dc.contributor.authorYanat, Ahmet Nedim
dc.contributor.authorTaşçi, Arzu
dc.date.accessioned2024-09-19T15:43:30Z
dc.date.available2024-09-19T15:43:30Z
dc.date.issued2006
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: We aimed in this study, to evaluate the effects and mechanism of action of single high-dose vitamin D3 and calcium on fracture healing in rats. Material and Methods: A total of 40 rats were divided into four groups; the first group (Group A) was treated with calcium, the second group (Group B) with vitamin D3, the third group (Group C) with calcium and vitamin D3 combination, and the fourth group was the control group (Group D). Tibiae of the rats were osteotomized by a Gigli saw. All rats were sacrificed 3 weeks after surgery. The results obtained were compared by mechanical testing, histological examination and radiographic evaluation. Results: Mean radiographic scores were 1.6 ± 0.8 for group D; 1.7 ± 0.8 for group A; 2.3 ± 0.8 for group B; and 2.4 ± 0.7 for group C. There was a statistically significant difference between the mean radiographic scores of only groups C and D (p = 0.037). There was also a statistically significant difference between the corresponding fracture load values of group D and all the other groups (p = 0.000), but there was no such difference between the corresponding fracture load values of the groups A and B (p = 0.208). Mean histological scores were 5.6 ± 2.7 for group D; 6.0 ± 2.7 for group A; 7.0 ± 2.1 for group B; and 7.2 ± 1.9 for group C (p> 0.05). Conclusion: These results suggested that the real effect of vitamin D on fracture healing was via calcium metabolism. We conclude that calcium and vitamin D given in the early stages of fracture healing gave opportunity for early weight bearing. Copyright © 2006 by Türkiye Klinikleri.en_US
dc.identifier.endpage513en_US
dc.identifier.issn1300-0292
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-33751226892en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage507en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14360
dc.identifier.volume26en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkiye Kliniklerien_US
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAngiogenesis inducing agentsen_US
dc.subjectCalciumen_US
dc.subjectCholecalciferolen_US
dc.subjectFracture healingen_US
dc.titleEffects of vitamin D3 and calcium on fracture healing in ratsen_US
dc.typeArticleen_US

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