Does cyclin E and p57kip2 expression have prognostic and survival value in colorectal adenocarcinoma?

dc.authoridAKDAG, ABDURRAHMAN/0000-0001-5292-8001
dc.authoridSumbul, Ahmet Taner/0000-0002-5573-906X
dc.contributor.authorOzgur, Tumay
dc.contributor.authorSumbul, Ahmet Taner
dc.contributor.authorYaldiz, Mehmet
dc.contributor.authorTemiz, Muhyittin
dc.contributor.authorAkdag, Abdurrahman
dc.date.accessioned2024-09-18T20:13:42Z
dc.date.available2024-09-18T20:13:42Z
dc.date.issued2018
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractIntroduction: Colorectal cancer is still one of the main causes of cancer death in the world. There is a continous need for novel biomarkers for diagnose, treatment modalities and follow-up. Cyclin E and p57(KIP2) as the positive and negative regulators of cell cycle seem to be an important target for investigations. Materials and methods: In a retrospective setting, primary colorectal adenocarcinoma cases examined in Mustafa Kemal University, School of Medicine, Pathology Department between 2008-2015 were reviewed. Immunohistochemical expressions of cyclin E and p57(KIP2) in 80 pairs of colorectal carcinoma and adjacent normal mucosal tissues were evaluated and the findings were compared with clinicopathological parameters and survival time. Results: There were no statistically significant difference between two groups both in cyclin E and p57(KIP2) stained tissues (P>0.05). There were 40 (50%) patients in high-expression group and 40 (50%) patients in low-expression group for cyclin E. P57(KIP2) was negative in 55 (68.75%) patients and positive in 25 (31.75%) patients. There were no statistically significant relation between p57(KIP2) and cyclin E expressions with clinicopathologic parameters defined as age, gender, lymphovascular invasion, perineural invasion, depth of invasion, nodal involvement, emergency in operation, perforation before operation and overall survival except that there was significant relation between p57(KIP2) expression and histological grade (P=0.012). Conclusions: Immunohistochemical studies of cyclin E and p57(KIP2) should be performed with larger series of patients supported by more detailed technical research methods to be candidates as predictive markers for treatment modalities and prognostic factors.en_US
dc.description.sponsorshipMustafa Kemal University Scientific Research Committee [13401]en_US
dc.description.sponsorshipWe would like to thank Dr. Tacettin Inandi from the Department of Public Health for his help in statistical analysis. This study was financially supported by Mustafa Kemal University Scientific Research Committee (Grant No: 13401).en_US
dc.identifier.endpage3875en_US
dc.identifier.issn1936-2625
dc.identifier.issue8en_US
dc.identifier.pmid31949774en_US
dc.identifier.startpage3867en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/9333
dc.identifier.volume11en_US
dc.identifier.wosWOS:000443312200005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCyclin Een_US
dc.subjectp57(KIP2)en_US
dc.subjectcolorectal adenocarcinomaen_US
dc.subjectimmunohistochemistryen_US
dc.titleDoes cyclin E and p57kip2 expression have prognostic and survival value in colorectal adenocarcinoma?en_US
dc.typeArticleen_US

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