What is the clinical significance of mixed apnea in patients with obstructive sleep apnea: A retrospective study
[ N/A ]
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Acta Medica Mediterranea
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: Mixed apnea is defined as absent inspiratory effort in the initial portion of apnea, followed by resumption of inspiratory effort in the second portion. However, the pathophysiological and clinical significance of mixed apnea has not been well defined. This study investigated the likely clinical importance of mixed apnea. Materials and methods: Patients diagnosed with severe obstructive sleep apnea (OSA) in polysomnographic studies were enrolled. Those with a mixed-apnea index value of 5/h or higher were grouped as mixed-OSA (Group 1), and those with a mixedapnea index value below 1/h were grouped as pure-OSA (Group 2). The patients' demographics, symptoms, clinical and polysomnographic findings, and laboratory examination results were reviewed retrospectively. Results: Groups 1 and 2 contained 24 and 42 patients, respectively. The mean age was significantly lower in Group 1 than those in Group 2 (47.4±10.4 vs 52.2±8.3, respectively, p<0.05). The patients in Group 1 displayed significantly higher apnea / hypopnea index (AHI) values (p <0.001). Sleep duration, arousal index, and duration of apneas were significantly higher in Group 1 (p=0,006, p=0.013, p=0.008, respectively). While minimum oxygen saturation and mean oxygen saturation levels were significantly lower (p<0.001), mean oxygen desaturation percentages were significantly higher in Group 1 than those in Group 2 (p=0,001). Conclusions: These findings suggest that mixed apnea is not just a subtype of obstructive apnea, and OSA with mixed apnea can be referred as a different fenotype of OSAS. Although there are studies about the alterations in neurochemical control of respiration, pathophysiology is not yet clear. So new studies are needed to investigate the underlying pathophysiology and and clinical outcome.
Açıklama
Anahtar Kelimeler
Central apnea, Intermittent hypoxia, Mixed apnea, Sleep apnea
Kaynak
Acta Medica Mediterranea
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
30
Sayı
2
