Caffeic acid phenethyl ester decreases the level of S-100B protein after middle cerebral after occlusion in rabbits

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dc.authorscopusid15823044400
dc.authorscopusid7004686098
dc.authorscopusid19933417600
dc.authorscopusid19933866500
dc.authorscopusid8944423300
dc.contributor.authorSerarslan, Yurdal
dc.contributor.authorBal, Ramazan
dc.contributor.authorAltu?, Muhammed Enes
dc.contributor.authorKontaş, Tünay
dc.contributor.authorMelek, Ismet Murat
dc.date.accessioned2024-09-19T15:45:21Z
dc.date.available2024-09-19T15:45:21Z
dc.date.issued2009
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractEffects of caffeic acid phenethyl ester (CAPE) on the serum S-100B levels were studied as an index for brain damage after permanent middle cerebral artery (MCA) occlusion in rabbits. Twenty rabbits were divided into four groups (n=5): control, sham, non-treatment and CAPE. The right MCA was occluded using a microsurgical procedure with bipolar coagulation and was then transected in non-treatment and CAPE groups. The rabbits in the sham group underwent a surgical procedure but the MCA was not occluded. No surgery was performed in the control group. CAPE was administered after MCA occlusion at the dose of 10?g/kg, once a day intraperitoneally for 7 days in the CAPE group. Serum S-100B levels were determined on days 1, 2, 4 and 7. Serum S-100B level was significantly increased following permanent MCA occlusion. Posttreatment of CAPE significantly reduced the serum S-100B level. This study demonstrated that CAPE is capable of attenuating increased serum S-100B level induced by MCA occlusion in rabbits. CAPE may be useful as a neuroprotective agent.en_US
dc.identifier.endpage316en_US
dc.identifier.issn1011-601X
dc.identifier.issue3en_US
dc.identifier.pmid19553181en_US
dc.identifier.scopus2-s2.0-68549110519en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage313en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/14608
dc.identifier.volume22en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofPakistan Journal of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrainen_US
dc.subjectCaffeic acid phenethyl esteren_US
dc.subjectCAPEen_US
dc.subjectExperimental strokeen_US
dc.subjectMCAen_US
dc.subjectMiddle cerebral artery occlusionen_US
dc.subjectS100Ben_US
dc.titleCaffeic acid phenethyl ester decreases the level of S-100B protein after middle cerebral after occlusion in rabbitsen_US
dc.typeArticleen_US

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