Relation of inflammatory markers with both presence and severity of hyperemesis gravidarum

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dc.authoridbenk silfeler, dilek/0000-0002-3533-0523
dc.contributor.authorKurt, Raziye Keskin
dc.contributor.authorGuler, Ayse
dc.contributor.authorSilfeler, Dilek Benk
dc.contributor.authorOzcil, Mustafa Dogan
dc.contributor.authorKarateke, Atilla
dc.contributor.authorHakverdi, Ali Ulvi
dc.date.accessioned2024-09-18T20:27:55Z
dc.date.available2024-09-18T20:27:55Z
dc.date.issued2014
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjectives: The aim of our study is to determine the newly introduced systemic inflammation marker, neutrophil lymphocyte ratio (NLR) in hyperemesis gravidarum (HG) patients and to investigate the association between severity of the disease and NLR. Method: The study population consisted of 55 pregnant patients with HG and 50 pregnant women without complaints matched for gestational age as a control group. The HG patients were grouped as mild (n=16), moderate (n=19) and severe (n=20) according to Modified Pregnancy-Unique Quantification of Emesis and Nausea Scoring Index Questionnaire. Furthermore, hsCRP, neutrophils, lymphocytes, and NLR were evaluated with complete blood count. Results: The HG group had significantly higher NLR values compared to the control group (2.69 +/- 1.81 vs 1.97 +/- 1.34, p=0.004). HsCRP levels were significantly higher among HG patients compared to the control group (1.95 +/- 2.2 vs 0.56 +/- 0.30, p<0.001). The subgroup analysis revealed statistically significant increases in NLR and hsCRP values with increased HG severity (p<0.001, p=0.002). The correlation analysis demonstrated a strong correlation between NLR and hsCRP levels (r: 0.703, p<0.001). Conclusion: Our study results showed that NLR and hsCRP levels are increased in HG disease compared to gestational age matched control group subjects. Furthermore, NLR and hsCRP values are correlated with severity of disease. NLR could be used as a marker for both presence and severity of hyperemesis gravidarum.en_US
dc.identifier.endpage593en_US
dc.identifier.issn0017-0011
dc.identifier.issn2543-6767
dc.identifier.issue8en_US
dc.identifier.pmid25219138en_US
dc.identifier.scopus2-s2.0-84907392057en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage589en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12483/10596
dc.identifier.volume85en_US
dc.identifier.wosWOS:000345957100004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofGinekologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecthyperemesis gravidarumen_US
dc.subjectinflammationen_US
dc.subjectneutrophil to lymphocyte ratioen_US
dc.subjecthsCRPIen_US
dc.titleRelation of inflammatory markers with both presence and severity of hyperemesis gravidarumen_US
dc.typeArticleen_US

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