Protective Effects of Beta Glucan and Gliclazide on Brain Tissue and Sciatic Nerve of Diabetic Rats Induced by Streptozosin

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dc.authoridEvliyaoglu, Osman/0000-0002-5780-9068
dc.authoridvarol, sefer/0000-0002-5007-7503
dc.contributor.authorAlp, Harun
dc.contributor.authorVarol, Sefer
dc.contributor.authorCelik, Muhammet Murat
dc.contributor.authorAltas, Murat
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorTokgoz, Orhan
dc.contributor.authorTanriverdi, Mehmet Halis
dc.date.accessioned2024-09-18T21:06:26Z
dc.date.available2024-09-18T21:06:26Z
dc.date.issued2012
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractThere have not been yet enough studies about effects of beta glucan and gliclazide on oxidative stress created by streptozotocin in the brain and sciatic nerve of diabetic rats. The aim of this paper was to investigate the antioxidant effects of gliclazide and beta glucan on oxidative stress and lipid peroxidation created by streptozotosin in brain and sciatic nerve. Total of 42 rats were divided into 6 groups including control, diabetic untreated (DM) (only STZ, diabetic), STZ (DM) + beta glucan, STZ (DM) + gliclazide, only beta glucan treated (no diabetic), and only gliclazide treated (no diabetic). The brain and sciatic nerve tissue samples were analyzed for malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase (PON-1) levels. We found a significant increase in MDA, TOS, and OSI along with a reduction in TAS level, catalase, and PON-1 activities in brain and sciatic nerve of streptozotocin-induced diabetic rats. Also, this study shows that in terms of these parameters both gliclazide and beta glucan have a neuroprotective effect on the brain and sciatic nerve of the streptozotocin-induced diabetic rat. Our conclusion was that gliclazide and beta glucan have antioxidant effects on the brain and sciatic nerve of the streptozotocin-induced diabetic rat.en_US
dc.description.sponsorshipDicle Universityen_US
dc.description.sponsorshipThis research was supported financially by the Dicle University.en_US
dc.identifier.doi10.1155/2012/230342
dc.identifier.issn1687-5214
dc.identifier.issn1687-5303
dc.identifier.pmid22291696en_US
dc.identifier.scopus2-s2.0-84856405899en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1155/2012/230342
dc.identifier.urihttps://hdl.handle.net/20.500.12483/13600
dc.identifier.wosWOS:000299534100001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofExperimental Diabetes Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidative Stressen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectDna-Damageen_US
dc.subjectNeuropathyen_US
dc.subjectApoptosisen_US
dc.subjectMellitusen_US
dc.subjectInjuryen_US
dc.titleProtective Effects of Beta Glucan and Gliclazide on Brain Tissue and Sciatic Nerve of Diabetic Rats Induced by Streptozosinen_US
dc.typeArticleen_US

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