Evaluation of the structure, autoimmunity, and functions of the thyroid gland in familial Mediterranean fever patients

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dc.authoridozcan, oguzhan/0000-0001-7486-503X
dc.authoridOzsan Yilmaz, Muge/0000-0001-8346-8941
dc.authoridOzturk KELES, Fatma/0000-0003-3430-1162
dc.contributor.authorYilmaz, Muge Ozsan
dc.contributor.authorCelik, Muhammet Murat
dc.contributor.authorKeles, Fatma Ozturk
dc.contributor.authorOzcan, Oguzhan
dc.date.accessioned2024-09-18T20:59:27Z
dc.date.available2024-09-18T20:59:27Z
dc.date.issued2020
dc.departmentHatay Mustafa Kemal Üniversitesien_US
dc.description.abstractObjective: Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disorder that is frequently seen in the eastern Mediterranean region. The thyroid gland can be affected in FMF patients through autoimmunity or amyloidosis. Here, we aimed to evaluate the structure and functions of the thyroid gland in addition to possible autoimmunity in FMF patients. Subjects and methods: The study was conducted by the Endocrinology and Metabolism and Internal Medicine Departments.Thirty FMF patients and 30 age and gender-matched healthy controls were enrolled in the study. Free thyroxin (fT4), free triiodothyronine (fT3), thyroid-stimulating hormone (TSH), and anti-thyroid peroxidase (anti-TPO) autoantibodies were investigated. Detailed thyroid grayscale and Doppler Ultrasonography examinations and shear-wave elastosonography (SWE) were performed in the patient and control groups. Results: Anti-TPO was detected in 24% (n = 7) of the patients. On the grayscale US, mean thyroid volumes were similar between the FMF and the control groups (p > 0.05). By Doppler US, thyroid vascularity observed was detected in 10.3% (n = 3) of the patients. SWE revealed that the mean velocity value of right vs. left lobe in the patient group was 1.77 +/- 0.45 m/s and 1.95 +/- 0.51 m/s, respectively. Compared to the control group, the mean velocity values were significantly higher in the right (p = 0.004) and left (p = 0.01) lobes of the patient group. The mean stiffness value in the patient group was also significantly higher in the right and left lobes [10.13 +/- 5.65 kPa (p = 0.005) and 12.24 +/- 6.17 kPa (p = 0.02), respectively]. Conclusion: Recognizing the complications of FMF early in the course of the disease is as important as the early diagnosis of the disorder. Based on this, thyroid functions and changes in its structure should be evaluated carefully for early diagnosis of a possible coexisting thyroid disorder.en_US
dc.identifier.doi10.20945/2359-3997000000198
dc.identifier.endpage70en_US
dc.identifier.issn2359-3997
dc.identifier.issn2359-4292
dc.identifier.issue1en_US
dc.identifier.pmid32187261en_US
dc.identifier.scopus2-s2.0-85081718795en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage66en_US
dc.identifier.urihttps://doi.org/10.20945/2359-3997000000198
dc.identifier.urihttps://hdl.handle.net/20.500.12483/12579
dc.identifier.volume64en_US
dc.identifier.wosWOS:000532470300012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSbem-Soc Brasil Endocrinologia & Metabologiaen_US
dc.relation.ispartofArchives of Endocrinology Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThyroiden_US
dc.subjectfamilial Mediterranean feveren_US
dc.subjectelastosonographyen_US
dc.subjectautoimmunityen_US
dc.titleEvaluation of the structure, autoimmunity, and functions of the thyroid gland in familial Mediterranean fever patientsen_US
dc.typeArticleen_US

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